Protein Alignment APP-BP1 and MOCS3

DIOPT Version :9

• Sequence 1: NP_001261699.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_055299.1
• Gene: MOCS3 / 27304
• HGNCID: 15765
• Length: 460
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 101/426 - (23%)
• Similarity: 141/426 - (33%)
• Gaps: 143/426 - (33%)

  Fly     3 SPAPKSPELS-DKSKKYDRQIRL--WGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTV 64
            ||.|....|| |:..:|.||:.|  .|.|||..|..|.|.:|....:||..|:.|...|:|...:
Human    47 SPLPPKAALSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGL 111

  Fly    65 ADGSTVKEEDLGNNFFLDSSYLGKSKALA-------------CMQLLQELNPDVNGDYV---DES 113
            .|...|:..:|........:..|::||.:             |:...|.|.|....|.|   |..
Human   112 VDYDVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVV 176

  Fly   114 AD--------------FLLANRPNFFDSFDLVIASNLNEQTLLLL------------------AE 146
            ||              .:||.||       ||.||.|..:..:.:                  ||
Human   177 ADCSDNVPTRYLVNDACVLAGRP-------LVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAE 234

  Fly   147 RLWELNVPLIYCRSLGMLGTIR-----LQIREHCIVEAH-PDNRQFDLRLEHPFDALREH----- 200
            .:..       |...|:||.:.     ||..|...:.|. ..:....|.|   |||||.|
Human   235 TVTN-------CADGGVLGVVTGVLGCLQALEVLKIAAGLGPSYSGSLLL---FDALRGHFRSIR 289

  Fly   201 --------------------LD-----GTEVTSKVPWLLVL--------------------HKYL 220
                                ||     |:..|.|...|.:|                    |..|
Human   290 LRSRRLDCAACGERPTVTDLLDYEAFCGSSATDKCRSLQLLSPEERVSVTDYKRLLDSGAFHLLL 354

  Fly   221 NVWQKQQADGTQTP------------RNYKEKNQLKETIREEMKADEENYEEAI----KAVNTAF 269
            :|..:.:.|..:.|            |:.:....|||.|.||.:..:|.....|    |..|.:.
Human   355 DVRPQVEVDICRLPHALHIPLKHLERRDAESLKLLKEAIWEEKQGTQEGAAVPIYVICKLGNDSQ 419

  Fly   270 GAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALK 305
            .|.::.:||.|..|.|   .|..:..|..:||.|.|
Human   420 KAVKILQSLSAAQELD---PLTVRDVVGGLMAWAAK 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	95/412 (23%)
		ThiF	17..>171	CDD:223552	49/208 (24%)
MOCS3	NP_055299.1	ThiF_MoeB_HesA_family	62..285	CDD:238386	59/239 (25%)
		RHOD_ThiF	327..460	CDD:238784	30/129 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810