DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and uba5

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_594376.2	Gene:	uba5 / 2543075	PomBaseID:	SPAC323.06c	Length:	517	Species:	Schizosaccharomyces pombe

Alignment Length:	534	Identity:	177/534 - (33%)
Similarity:	282/534 - (52%)	Gaps:	41/534 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLG 76
            |.|.:|||||:|||...||..:|.:.|||:....||||..|.|:|||||.|.|.|.::|.....|
pombe     4 SAKMQKYDRQVRLWKAEGQNAIEKSHVCLLYANTVGCEALKNLILPGIGSFAVVDDTSVDFSMDG 68

  Fly    77 NNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTL 141
            .|||:.....|||:|.....|||:|||:|..:|::.|.:.|:.....:|..|.:|::|||.|:.|
pombe    69 MNFFIQYDQEGKSRARCTASLLQQLNPNVEMEYLEMSPEALIDKNIEYFSKFSVVLSSNLKEKPL 133

  Fly   142 LLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDAL--------R 198
            ..|.|.|....:||::..|:|..|.:|:...|:...::.|:..| ||||::|:..|        .
pombe   134 FRLEEYLRSHKIPLLHFNSVGFAGILRISTHEYTTTQSQPELPQ-DLRLKNPWPELINYVKSMDL 197

  Fly   199 EHLDGTEVTSKVPWL-LVLHKYLNV-----WQKQQADGTQTPRNYKEKNQLKETIREEM--KADE 255
            :::|.:.: |::|:: |::|..|.|     ...|:||.....|.          |.||.  |.|.
pombe   198 DNMDSSSL-SEIPYIVLIIHVLLKVSPAHAQNSQEADDCAMFRK----------IMEEYKGKCDS 251

  Fly   256 ENYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPG 320
            ||.|||......||...::|.::..:..|..|.::.:.|..|||||..||.|  ::....|||.|
pombe   252 ENIEEASSNSWKAFKEYKLPSNVYEVLHDTRCVKIQEDSESFWIMAHCLKMF--YDETEFLPLSG 314

  Fly   321 VLPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAV 385
            :||||..:|..|:.||.||::::..|..:.....|:.||:|....:.|.:..::...:....:.|
pombe   315 LLPDMNCSTQQYVKLQVIYKEKSENDILKFKKYVQQTLKRLNRSVEEITDLEIKHFSRNCLNIKV 379

  Fly   386 IRGTRIAEEYEKSSRLLPLVEDNELQGN-LTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKS 449
            :....:.|||:.:|.  .::|.:.:..| |..:..|.|.|:..|.:.|....|..  .|..:..|
pombe   380 MDFKTMKEEYQPTSN--SVLESSSIDSNSLLPWYLAFRIYDTILEKHGKNYKEAF--SDTTKTIS 440

  Fly   450 IAAKMLSDLGMHATISDDVLH----EICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTF 510
            :|...||.:|:....  ||::    |:.|..|.|||::|:||||..|||.||::.:||.|::|||
pombe   441 VAQSFLSQIGLEKFF--DVVYTAIQELERADGHELHSISSFIGGIVAQETIKLLAQQYLPLNNTF 503

  Fly   511 IYNAITTESVTLKL 524
            :::.:.:.:.|.||
pombe   504 VFDGVHSRTETFKL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	172/526 (33%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	64/153 (42%)
uba5	NP_594376.2	ThiF	1..>218	CDD:223552	80/215 (37%)
		APPBP1_RUB	8..515	CDD:238770	172/526 (33%)
		E1_enzyme_family	<425..507	CDD:304554	32/85 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	267	1.000	Domainoid score	I347
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I686
OMA	1	1.010	-	-		QHG54417
OrthoFinder	1	1.000	-	-		FOG0003676
OrthoInspector	1	1.000	-	-		oto101152
orthoMCL	1	0.900	-	-		OOG6_101722
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1600
SonicParanoid	1	1.000	-	-		X3040
TreeFam	1	0.960	-	-
	13	12.860