DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and Nae1

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_659180.1	Gene:	Nae1 / 234664	MGIID:	2384561	Length:	534	Species:	Mus musculus

Alignment Length:	533	Identity:	240/533 - (45%)
Similarity:	343/533 - (64%)	Gaps:	29/533 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNN 78
            |.:|||||:||||:|||..||:|.|||:|.||.|.|..|.|||||||.||:.||:.|..||.|||
Mouse     9 KEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNLVSGEDAGNN 73

  Fly    79 FFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLLL 143
            |||..|.:||::|.|.|:.|||||.||:|.:|:||.:.||.|.|:||..|.:|:|:.|.|.|||.
Mouse    74 FFLQKSSIGKNRAQAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLR 138

  Fly   144 LAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVT- 207
            ||:.||...:||:.||:.|::|.:|:.|:||.::|:||||...||||:.||..|||||...::.
Mouse   139 LADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHLQSYDLDH 203

  Fly   208 ------SKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEM-------KADEENYE 259
                  |..||::::.|||..|. .:.:| :.|::||||...::.||:.:       ..||||:|
Mouse   204 MEKKDHSHTPWIVIIAKYLAQWY-NETNG-RIPKSYKEKEDFRDLIRQGILKNENGAPEDEENFE 266

  Fly   260 EAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPD 324
            ||||.||||....|:|.|::.||.||.|..:.|::..|||:|:|||.||..|.:|:||:.|.:||
Mouse   267 EAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPTFWILARALKEFVAKEGQGNLPVRGTIPD 331

  Fly   325 MTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGT 389
            |.|:::.||.||::||::|.:||..|.:...:.|:.:....:||.|:.::|:|..:|.|.|:|..
Mouse   332 MIADSNKYIKLQNVYREKAKKDAAAVGNHVAKLLQSVGQAPESISEKELKLLCSNSAFLRVVRCR 396

  Fly   390 RIAEEY----EKSSRLLPLVE--DNELQGNLTAYNFALRAYERFLSECGNIPG--ECIVEQDIGR 446
            .:||||    .....::..::  |||:     .....|||.:||..:.|..||  ...||:|||:
Mouse   397 SLAEEYGLDTVNKDEIISSMDNPDNEI-----VLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIGK 456

  Fly   447 LKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFI 511
            |||.....|.:.|:...:.||.:||.||||.||.|.::||:||.||||||||||||:...:||:|
Mouse   457 LKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYI 521

  Fly   512 YNAITTESVTLKL 524
            |:.::..|.|.:|
Mouse   522 YSGMSQTSATFQL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	237/527 (45%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	86/153 (56%)
Nae1	NP_659180.1	ThiF	9..>193	CDD:223552	101/183 (55%)
		APPBP1_RUB	11..532	CDD:238770	237/527 (45%)
		Interaction with UBA3. /evidence=ECO:0000250	331..344		6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831660
Domainoid	1	1.000	444	1.000	Domainoid score	I533
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68370
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1540
Isobase	1	0.950	-	0	Normalized mean entropy	S2092
OMA	1	1.010	-	-		QHG54417
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003676
OrthoInspector	1	1.000	-	-		oto93333
orthoMCL	1	0.900	-	-		OOG6_101722
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1600
SonicParanoid	1	1.000	-	-		X3040
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740