Protein Alignment APP-BP1 and Uba1

DIOPT Version :10

• Sequence 1: NP_648435.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_033483.3
• Gene: Uba1 / 22201
• MGIID: 98890
• Length: 1058
• Species: Mus musculus
• Alignment Length: 563
• Identity: 112/563 - (19%)
• Similarity: 178/563 - (31%)
• Gaps: 193/563 - (34%)

  Fly     1 MSSPAPK-----SPELSDKSK---------------------KYDRQIRLWGEHGQTLLEAATVC 39
            :|.|.||     ||..|..|:                     .|.||:.:.|.....:|:.::|.
Mouse    12 VSGPDPKPGSNCSPAQSALSEVSSVPTNGMAKNGSEADIDESLYSRQLYVLGHEAMKMLQTSSVL 76

  Fly    40 LVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALACMQLLQELNPD 104
            :..:..:|.|.||.::|.|:...|:.|..|.:..||.:.|:|....:||::|......|.|||..
Mouse    77 VSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSY 141

  Fly   105 V-----NGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLLLLAERLWELNVPLIYCRSLGML 164
            |     .|..|::           |..||.:|:.:|...:..|.:.|......:.|:...:.|:.
Mouse   142 VPVTAYTGPLVED-----------FLSSFQVVVLTNSPLEAQLRVGEFCHSRGIKLVVADTRGLF 195

  Fly   165 GTIRLQIREHCIVEAHPDNRQFDLRLEHPFDA---------------LREHLDGTEVTSKVPWLL 214
            |.:.....|..::.        |...|.|..|               |.|...|.|....|
Mouse   196 GQLFCDFGEEMVLT--------DSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFETGDFV---- 248

  Fly   215 VLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKA--VNTAFGAGQVPKS 277
               .:..|....|.:|.| |...|.......:|     .|..|:.:.|:.  |:..    :|||
Mouse   249 ---SFSEVQGMIQLNGCQ-PMEIKVLGPYTFSI-----CDTSNFSDYIRGGIVSQV----KVPK- 299

  Fly   278 LKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPDMTANTDSYIALQHIYRQQ 342
                       :::.||                     ||...|.||... ||    .....|..
Mouse   300 -----------KISFKS---------------------LPASLVEPDFVM-TD----FAKYSRPA 327

  Fly   343 ALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVED 407
            .|....|..|:......|...|.:..|       ..|..|||          ...::|..|.|:.
Mouse   328 QLHIGFQALHQFCALHNQPPRPRNEED-------ATELVGLA----------QAVNARSPPSVKQ 375

  Fly   408 NELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEI 472
            |.|                                                      .:|::.::
Mouse   376 NSL------------------------------------------------------DEDLIRKL 386

  Fly   473 CRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNAI 515
            ......:|..::|||||.|||||:|..:.::.||.....::|:
Mouse   387 AYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDAL 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_648435.1	APPBP1_RUB	16..522	CDD:238770	104/543 (19%)
Uba1	NP_033483.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		8/33 (24%)
		2 approximate repeats	63..611		101/512 (20%)