Protein Alignment APP-BP1 and SAE1

DIOPT Version :9

• Sequence 1: NP_001261699.1
• Gene: APP-BP1 / 39244
• FlyBaseID: FBgn0261112
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_005491.1
• Gene: SAE1 / 10055
• HGNCID: 30660
• Length: 346
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 103/507 - (20%)
• Similarity: 163/507 - (32%)
• Gaps: 190/507 - (37%)

  Fly    13 DKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGN 77
            :::.:|||||||||...|..|.|:.|.||.:..:|.|.||.|:|.|:.|.|:.|...|..||.|.
Human    14 EEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGA 78

  Fly    78 NFFLDSSYLGKSKALACMQLLQELNP--DVNGDYVDESADFLLANRP-NFFDSFDLVIASNLNEQ 139
            .|.:.:..:|:::|.|.::..|.|||  ||..|..|      :..:| :||..||.|..:..:..
Human    79 QFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTED------IEKKPESFFTQFDAVCLTCCSRD 137

  Fly   140 TLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGT 204
            .::.:.:...:.::........|..|.....:.||..||......:....:|...|..|..||.:
Human   138 VIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSS 202

  Fly   205 EVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNTAF 269
            |.|
Human   203 ETT-------------------------------------------------------------- 205

  Fly   270 GAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPDMTANTDSYIA 334
                                :.||..||..:.:||
Human   206 --------------------MVKKKVVFCPVKEAL------------------------------ 220

  Fly   335 LQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEEYEKSS 399
                       :.|....|.:..||                              |...:|
Human   221 -----------EVDWSSEKAKAALK------------------------------RTTSDY---- 240

  Fly   400 RLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLGMHATI 464
                               |.|:...:|.::.|..|.....|:|...|..|...:|..||    |
Human   241 -------------------FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLG----I 282

  Fly   465 SDDVLHE-ICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNAI 515
            |.|:|.| ..||..:|:..|.|.:||..|||::|.::::..|.:|.|.::.:
Human   283 SPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	103/504 (20%)
		ThiF	17..>171	CDD:223552	49/156 (31%)
SAE1	NP_005491.1	Aos1_SUMO	16..341	CDD:238769	103/505 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1600
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840