DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irbp18 and Cebpb

DIOPT Version :9

Sequence 1:	NP_001261698.1	Gene:	Irbp18 / 39243	FlyBaseID:	FBgn0036126	Length:	113	Species:	Drosophila melanogaster
Sequence 2:	NP_034013.1	Gene:	Cebpb / 12608	MGIID:	88373	Length:	296	Species:	Mus musculus

Alignment Length:	86	Identity:	27/86 - (31%)
Similarity:	48/86 - (55%)	Gaps:	10/86 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAKKRTAASTSKNSDSPLSPHTDDPAYKEKRKKNNEAVQRTREKTKKSAEERKKRIDDLRKQNDA 66
            |||.:...:..|.||.          ||.:|::||.||:::|:|.|....|.:.::.:|..:|:.
Mouse   209 PAKAKAKKTVDKLSDE----------YKMRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENER 263

  Fly    67 LKVQIETSEKHISTLRDLIIQ 87
            |:.::|...:.:||||:|..|
Mouse   264 LQKKVEQLSRELSTLRNLFKQ 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irbp18	NP_001261698.1	bZIP_CEBP	24..83	CDD:269841	18/58 (31%)
Irbp18	NP_001261698.1	coiled coil	25..83	CDD:269841	18/57 (32%)
Cebpb	NP_034013.1	Required for Lys-133 sumoylation. /evidence=ECO:0000250\|UniProtKB:P17676	1..22
		Required for MYC transcriptional repression. /evidence=ECO:0000269\|PubMed:16585579	22..104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..199
		bZIP_CEBPB	215..285	CDD:269860	24/80 (30%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	226..246		9/19 (47%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	248..255		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43756
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4506
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840