Protein Alignment JIL-1 and LATS1

DIOPT Version :10

• Sequence 1: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Alignment Length: 855
• Identity: 210/855 - (24%)
• Similarity: 317/855 - (37%)
• Gaps: 257/855 - (30%)

  Fly    13 SGTSTSRLKNHQHPRESESLAYEEPDQMVRNHLNGQ----LVANG--------NGKTRK-----N 60
            :||..:....||:...:.::..:.|........|||    |...|        ||...:     |
Human   349 NGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPN 413

  Fly    61 SNSETM-----------TNGKKSKLNTEGSGSGSG------------KTLNYNNNNNNNNSISAT 102
            .||..|           ||..:|......|...||            ::.::||...|..|.||.
Human   414 RNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSAN 478

  Fly   103 NGQYTNSSSKTTSA-----------------SARDYTYR-------ETISPPTPPSPPTTNVADI 143
            :.....:.:..|.|                 :|...|:.       :|:.|...|....:||..:
Human   479 SQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVM 543

  Fly   144 VCISDAESEDGRD--------------PEREYYDQDMEEDEPNGIEIDESSSSLSKAKSNNAAAA 194
            ..:::|.:..|..              |..|...:..:||:|:..:.|||..|.....|.:....
Human   544 PPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKK 608

  Fly   195 AAAAAAAAAAAASK---ASSSTTPSYAMPTSNSTPLD--LDN--EAHQRDLEAVTDLK------- 245
            ....:........|   ...|...||: |.:....::  ::|  ::||:.|.....|:
Human   609 QITTSPITVRKNKKDEERRESRIQSYS-PQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVG 672

  Fly   246 ------------------YYVKL---YSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKL 289
                              .|::|   ..|:::    |..|:.||.||:|.|.|.||:   |...|
Human   673 LSQDAQDQMRKMLCQKESNYIRLKRAKMDKSM----FVKIKTLGIGAFGEVCLARKV---DTKAL 730

  Fly   290 YAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTH 354
            ||.|.|.|..|:.:.:.| |.|.||.:| |...|.::|.|:|:||....||.|:|:..||::.:.
Human   731 YATKTLRKKDVLLRNQVA-HVKAERDIL-AEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSL 793

  Fly   355 LYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGL--------- 410
            |.....|.||..|.||||:..|:|.:|::|.|:||||.:|||:|.:|||.|:||||
Human   794 LIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHD 858

  Fly   411 SKI-----------LTAENEY--------------------------RAHSFCGTLEYMAPEI-I 437
            ||.           :...||:                          .|||..||..|:|||: :
Human   859 SKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLL 923

  Fly   438 RTGPPGHDSAVDWWSVGVLTFELLTGASPF--------------------------------ATS 470
            ||   |:....|||||||:.||:|.|..||                                .|.
Human   924 RT---GYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKPGMVAHTCNPSALEGHSRKNTGTQ 985

  Fly   471 DGQVQQSEISRRIQKEQPMIP-SSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGIN 534
            :.::....|....|....:.| :..|..|.|.::|:. :.|:.|||.|  .|.|||.||||..|:
Human   986 EFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKLC-RGPEDRLGKN--GADEIKAHPFFKTID 1047

  Fly   535 W-QELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPED--------------------PECDAPP 578
            : .:||  ::.|.|.|.:|...|..||.....|::..|                    ||.....
Human  1048 FSSDLR--QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYE 1110

  Fly   579 SRIRLF---RGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPCRPDDLELGTRTSNGAYGTCHFV 640
            ...|.|   .||.|..|:.:         |.:|.|:.........||...|:...|
Human  1111 FTFRRFFDDNGYPYNYPKPI---------EYEYINSQGSEQQSDEDDQNTGSEIKN--------- 1157

  Fly   641 VDSSTDLVFL 650
                .|||::
Human  1158 ----RDLVYV 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	116/346 (34%)
		S_TK_X	532..591	CDD:214529	19/82 (23%)
		S_TKc	632..886	CDD:214567	3/19 (16%)
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580
		PRK10263	<448..>596	CDD:236669	26/147 (18%)
		MobB_LATS1	629..704	CDD:439273	12/75 (16%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	133/430 (31%)