Protein Alignment JIL-1 and YPK1

DIOPT Version :10

• Sequence 1: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_012796.1
• Gene: YPK1 / 853733
• SGDID: S000001609
• Length: 680
• Species: Saccharomyces cerevisiae
• Alignment Length: 673
• Identity: 200/673 - (29%)
• Similarity: 313/673 - (46%)
• Gaps: 115/673 - (17%)

  Fly    13 SGTSTSRLKNHQHPRESESLAYEEPDQMVRNHLNGQLVANGNGKTRKNSNSETMT-----NGKKS 72
            ||...|..|..|  :.:::.|.|....:.|:.|:.:...|       .|||..:.     :...|
Yeast    22 SGFFHSSKKEEQ--QNNQATAGEHDASITRSSLDRKGTIN-------PSNSSVVPVRVSYDASSS 77

  Fly    73 KLNTEGSGSGSGKTLNYNNNNNNNNSISATNGQYTNSSSKTTSASARDYTYRETISP-PTPPS-- 134
            ......|..|:.:..|.:.|.:...:|.:| |...:::|.:...:.:.|...:.|.| |...|
Yeast    78 TSTVRDSNGGNSENTNSSQNLDETANIGST-GTPNDATSSSGMMTIKVYNGDDFILPFPITSSEQ 141

  Fly   135 -----------PPTTNVADIVCISDAESEDGRDPEREYYDQDMEEDE------PNGIEIDESSSS 182
                       ||...::..|....|:....:...:...|:|:...|      |:.|.: ..||:
Yeast   142 ILNKLLASGVPPPHKEISKEVDALIAQLSRVQIKNQGPADEDLISSESAAKFIPSTIML-PGSST 205

  Fly   183 LSKAK------SNNAAAAAAAAAAAAAAAASKASS---------------STTPSYAMPTSN-ST 225
            |:...      .|..|...|.....|....:|.|:               :..||..:|:.. ..
Yeast   206 LNPLLYFTIEFDNTVATIEAEYGTIAKPGFNKISTFDVTRKLPYLKIDVFARIPSILLPSKTWQQ 270

  Fly   226 PLDLDNEAHQRDLEAVT------------------DLKYYVKLYS-------------------- 252
            .:.|.:|..|...:.:.                  |....::||:
Yeast   271 EMGLQDEKLQTIFDKINSNQDIHLDSFHLPINLSFDSAASIRLYNHHWITLDNGLGKINISIDYK 335

  Fly   253 ---DEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTER 314
               ::.:|::||.:::|:|.|::|:|..|||   .|..|:||:|.:.|..:|.|.:.. ||..||
Yeast   336 PSRNKPLSIDDFDLLKVIGKGSFGKVMQVRK---KDTQKVYALKAIRKSYIVSKSEVT-HTLAER 396

  Fly   315 VVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQ 379
            .||..:. .||:|.|.::|||..|||.||.|.||||||.||.....|:.||.|.|.||::.||:.
Yeast   397 TVLARVD-CPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDN 460

  Fly   380 LHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGH 444
            ||:|.::|||:|.||||||.:|||.|.||||.| |..:::.:..:||||.||:|||::.  ..|:
Yeast   461 LHKLDVVYRDLKPENILLDYQGHIALCDFGLCK-LNMKDDDKTDTFCGTPEYLAPELLL--GLGY 522

  Fly   445 DSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKN 509
            ..|||||::|||.:|:|||..|:...|    ..::.::|.:|..:.|..|..:|:|.::.:|.::
Yeast   523 TKAVDWWTLGVLLYEMLTGLPPYYDED----VPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRD 583

  Fly   510 PKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPEC 574
            |.||||.|  .|.||:.||||:.::|:.|..|....||||.::...|..||..|||.:.|.|...
Yeast   584 PTRRLGYN--GADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDEEFTREKPIDSVV 646

  Fly   575 D--APPSRIRLFRGYTYVAPEHL 595
            |  ...|..:.|.|:|||..|.|
Yeast   647 DEYLSESVQKQFGGWTYVGNEQL 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	119/266 (45%)
		S_TK_X	532..591	CDD:214529	21/60 (35%)
		S_TKc	632..886	CDD:214567
YPK1	NP_012796.1	YPK1_N_like	116..342	CDD:212165	32/226 (14%)
		Protein Kinases, catalytic domain	352..663	CDD:473864	138/324 (43%)