Protein Alignment JIL-1 and RIM15

DIOPT Version :10

• Sequence 1: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_116620.1
• Gene: RIM15 / 850511
• SGDID: S000001861
• Length: 1770
• Species: Saccharomyces cerevisiae
• Alignment Length: 1330
• Identity: 248/1330 - (18%)
• Similarity: 426/1330 - (32%)
• Gaps: 555/1330 - (41%)

  Fly    44 HLNGQLVANGNGKTRKNSNSETMTNGKKSKLNTEGSGSGSGKTLNYNNNNNNNNSISATNGQYTN 108
            :||..::.|.:.::..:.:.:..||.:.|.:...|.|                   .||:.:.:|
Yeast   570 YLNADIIPNPSIESTISIDRDNNTNSRGSSMKQYGIG-------------------EATDSRTSN 615

  Fly   109 SSSKTTSAS-----ARDYTYRETISPPTPPSPPTTNVADIVCISDAESEDGRDPEREYYDQDMEE 168
            |...::|:|     :|..|.|:.|.                 .|..:::| |..|....|:|..:
Yeast   616 SERPSSSSSRLGIRSRSITPRQKIE-----------------YSHVDNDD-RTNEMLSRDKDSLQ 662

  Fly   169 DEPNGIEID-------ESSSSLSKAKSNNAAAAAAAAAAAAAAAASKASS---STTPSYAMPTSN 223
            .:|:   :|       :::::.:|..|||:..:.......:.:...:..|   ....|::|..:|
Yeast   663 PQPS---VDTTITSSTQATTTGTKTNSNNSTNSVLPKLMTSISLTPRRGSPSFGNLASHSMQQTN 724

  Fly   224 S-------TPLD---------LDNEAHQRDLEAVTDLKYYVKLYS------------DEAV---- 256
            |       :|:.         |..|.|..:: |.||......|.|            ::.|
Yeast   725 SFKLIHDKSPISSPFTFSKDFLTPEQHPSNI-ARTDSINNAMLTSPNMPLSPLLLATNQTVKSPT 788

  Fly   257 -SLNDFKIIRVLGTGAYGRVFLVR-KLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEA 319
             |:.|:.|::.:..||||.|:|.| |||    |..:|:|||.|..::.|.:.. :.|:||.::..
Yeast   789 PSIKDYDILKPISKGAYGSVYLARKKLT----GDYFAIKVLRKSDMIAKNQVT-NVKSERAIMMV 848

  Fly   320 IQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLG 384
            ....|::..|..:||:...|:||:::..||:|.|.:.......:...:.|:.|:|:.:..:||.|
Yeast   849 QSDKPYVARLFASFQNKDNLFLVMEYLPGGDLATLIKMMGYLPDQWAKQYLTEIVVGVNDMHQNG 913

  Fly   385 IIYRDIKLENILLDGEGHIVLSDFGLSKI-----------------------------LTAEN-- 418
            ||:.|:|.||:|:|..||:.|:|||||:.                             .|..|
Yeast   914 IIHHDLKPENLLIDNAGHVKLTDFGLSRAGLIRRHKFVPHKSSLSISSTLPIDNPANNFTMNNNN 978

  Fly   419 ----------------------------------EY----------------------------R 421
                                              ||                            |
Yeast   979 SNHSQLSTPDSFTSDHKQYNRSKKSSLGQQYEHSEYSSTSNSHSMTPTPSTNTVVYPSYYRGKDR 1043

  Fly   422 AH--------------------------------------------------------------- 423
            :|
Yeast  1044 SHGSSNIDLPASLRRSESQLSFSLLDISRSSTPPLANPTNSNANNIMRRKSLTENKSFSNDLLSS 1108

  Fly   424 -------------------------------------SFCGTLEYMAPEIIRTGPPGHDSAVDWW 451
                                                 .|.||.:|:|||.|. |....:...|||
Yeast  1109 DAIAATNTNINSNNNISLSPAPSDLALFYPDDSKQNKKFFGTPDYLAPETIE-GKGEDNKQCDWW 1172

  Fly   452 SVGVLTFELLTGASPF--ATSD--------GQVQQSEISRRIQKEQPMIPSSFSANARDFVLKML 506
            |||.:.||||.|..||  .|.|        |.:|..|.....::.:.:.|     .|:|.:.|:|
Yeast  1173 SVGCIFFELLLGYPPFHAETPDAVFKKILSGVIQWPEFKNEEEEREFLTP-----EAKDLIEKLL 1232

  Fly   507 EKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFS------NEFT 565
            ..:|.:|||.  :...|||:||:|..::|..:..:  :|.:.||:...:|...|.      .:|.
Yeast  1233 VVDPAKRLGA--KGIQEIKDHPYFKNVDWDHVYDE--EASFVPTIDNPEDTDYFDLRGAELQDFG 1293

  Fly   566 DQVPED---------------PECDA----PP-------------------------SRIRLFRG 586
            |.:..|               .|..|    ||                         |.:..|..
Yeast  1294 DDIENDNANILFGKHGINTDVSELSAANLSPPLNHKNILSRKLSMSNTTNRSSNNSNSSVHDFGA 1358

  Fly   587 YTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPCRPDDLELGTRTSNGAYGTCHFVVDSSTDLVFLA 651
            :|.|           |...|.   :.|:::|     .|.|..|.||. ||......:|.:|..|:
Yeast  1359 HTPV-----------NKLSIA---SVLESVP-----QETGYITPNGT-GTTTTSAKNSPNLKNLS 1403

  Fly   652 KIIP-------LSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASI 709
            ..||       .||...|:.:                  .|:|..:             .|:|..
Yeast  1404 LAIPPHMRDRRSSKLNDSQTE------------------FGSFNFR-------------NLSALD 1437

  Fly   710 RMDEDSCREIFLQLVMAVRHIHSKHF-----IH------------------------------GD 739
            :.::|           |:..:.|:||     :|                              |.
Yeast  1438 KANKD-----------AINRLKSEHFSEQPGVHRRTSSASLMGSSSDGSVSTPGSNASNTTSGGK 1491

  Fly   740 LK----------------PENIM----FENRE---DRTVKLIDF------GSACYNNR--FKSWK 773
            ||                |:..:    |..|.   :|::. ||.      ||...:|:  ..:..
Yeast  1492 LKIHKPTISGSPSTFGTFPKTFLRSDSFSTRSYSPERSIS-IDSSTLSRKGSIIGDNQQTTANSS 1555

  Fly   774 DKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRK 838
            |.|..|...:|   |:.||..|.|.......:.:..::...........|.|...:.:..:.||.
Yeast  1556 DSPTMTKFKSP---LSPANTTTVSSYFSRQRVLSKSFSQRTNSSDLSAEESDRLQAISRVNSLRN 1617

  Fly   839 RMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDS------------EWLQYGSN 891
            |.|.|      .:..|.|....|:.....:..|..|..::..|::            |.:...::
Yeast  1618 RRRSG------RKSSSTSEIGYHMDVLVCEPIPIHRYRVTKDLENLGCTVVSVGAGDELVSRATS 1676

  Fly   892 DPDVDII-----LPQQMVVDL-------------------------------SEDTMEQPTGGMF 920
            ....|:|     ||:...:|:                               .:|.:|:|.  ..
Yeast  1677 GVSFDLIMTALKLPKLGAIDIVQLLKQTNGANSTTPIVAITNYFQEAATSRVFDDVLEKPV--KL 1739

  Fly   921 DDQQQL--EFMHDKSAEDEGITLVSEPMDT 948
            |:.::|  ::...||.|||..|::|:..:|
Yeast  1740 DELKKLVAKYALKKSQEDEEHTILSDSDET 1769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	101/470 (21%)
		S_TK_X	532..591	CDD:214529	16/108 (15%)
		S_TKc	632..886	CDD:214567	56/338 (17%)
RIM15	NP_116620.1	Protein Kinases, catalytic domain	797..1260	CDD:473864	101/475 (21%)
		S_TK_X	1255..>1298	CDD:214529	8/44 (18%)
		REC_hyHK_CKI1_RcsC-like	1637..1746	CDD:381099	13/110 (12%)