DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and Rps6kb1

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_114191.1	Gene:	Rps6kb1 / 83840	RGDID:	620683	Length:	525	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	157/341 - (46%)
Similarity:	223/341 - (65%)	Gaps:	10/341 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 FKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPF 325
            |:::||||.|.||:||.|||:|..:.||::|||||.|..:|:..|...|||.||.:||.: ::||
  Rat    91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV-KHPF 154

  Fly   326 LVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDI 390
            :|.|.||||:..||||:|::.:|||||..|.....|.|.....|:||:.:||..|||.||||||:
  Rat   155 IVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219

  Fly   391 KLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGV 455
            |.|||:|:.:||:.|:||||.|....:... .|:||||:|||||||:...  ||:.||||||:|.
  Rat   220 KPENIMLNHQGHVKLTDFGLCKESIHDGTV-THTFCGTIEYMAPEILMRS--GHNRAVDWWSLGA 281

  Fly   456 LTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRD 520
            |.:::||||.||.   |:.::..|. :|.|.:..:|...:..|||.:.|:|::|...|||....|
  Rat   282 LMYDMLTGAPPFT---GENRKKTID-KILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGD 342

  Fly   521 ASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDA--PPSRIRL 583
            |.|::.||||..|||:||..::.:.|:||.|.:|:||..|.::||.|.|.|...|:  ..|..::
  Rat   343 AGEVQAHPFFRHINWEELLARKVERPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQV 407

  Fly   584 FRGYTYVAPEHLEQMR 599
            |.|:|||||..||.::
  Rat   408 FLGFTYVAPSVLESVK 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	126/268 (47%)
		STKc_MSK_N	266..533	CDD:270735	126/266 (47%)
		S_TK_X	532..591	CDD:214529	24/60 (40%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
Rps6kb1	NP_114191.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54
		TOS motif	28..32
		S_TKc	91..352	CDD:214567	126/268 (47%)
		STKc_p70S6K	94..416	CDD:270736	152/329 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..399		7/18 (39%)
		Autoinhibitory domain	424..525		157/341 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850