DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and Rps6ka6

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_080225.2	Gene:	Rps6ka6 / 67071	MGIID:	1914321	Length:	860	Species:	Mus musculus

Alignment Length:	748	Identity:	253/748 - (33%)
Similarity:	371/748 - (49%)	Gaps:	96/748 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 ASSSTTPSYAMPTSNSTPLDLDNEAHQRDLEAVTDLKYYVK-LYSDEAVSLN------------- 259
            ::||:.|.......|:..:..::|..:     |.|||...: :...|.||..
Mouse   117 STSSSEPQVVFTMKNAATVMREHERKE-----VNDLKMVDEPMEEGEPVSCRREELVKEIPITQH 176

  Fly   260 -----------DFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTE 313
                       .|.:::|||.|::|:||||||.|..|||:|||||||.|.::  |.:....||.|
Mouse   177 VKEGYEKADPAQFDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASL--KVRDRVRTKME 239

  Fly   314 RVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALE 378
            |.:|..: .:||:|.||||||:..||||:|||..||::||.|.....|.|..|:.|:||:.|||:
Mouse   240 RDILVEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 303

  Fly   379 QLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPG 443
            .||:|||:|||:|.||||||..|||.|:|||||| .:.:.|.:|:|||||:||||||::..  .|
Mouse   304 HLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSK-ESVDQEKKAYSFCGTVEYMAPEVVNR--RG 365

  Fly   444 HDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEK 508
            |..:.||||.|||.||:|||..||...|    ::|....|.|.:..:|...||.|:..:..:.::
Mouse   366 HSQSADWWSYGVLMFEMLTGTLPFQGKD----RNETMNMILKAKLGMPQFLSAEAQSLLRMLFKR 426

  Fly   509 NPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPED-P 572
            ||..|||.  ....|:|.|.||..|:|.:|..:..:.|::|.....||...|..|||.:.|:| |
Mouse   427 NPANRLGS--EGVEEVKRHAFFASIDWNKLYKREVQPPFRPASGKPDDTFCFDPEFTAKTPKDSP 489

  Fly   573 ECDAPPSRIRLFRGYTYVAPEHLEQMR-----RDNHCEIQYFNTGLQNIPCRPDDLELGTRTSNG 632
            ...|..:..:||:|:::||....|:.:     ..|...|...|   .|.....:..||......|
Mouse   490 GLPASANAHQLFKGFSFVATSIAEEYKITPVTSSNVLPIVQIN---GNAAQFSEAYELKEDIGIG 551

  Fly   633 AYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVM 697
            :|..|...:.|::::.|..|||..:|..|||.   |...:....|.||:|....|.:....::|.
Mouse   552 SYSVCKRCIHSASNVEFAVKIIDKNKRDPSEE---IEILMRYGQHPNIISLKEVFDDGKYVYLVT 613

  Fly   698 EYLSGPELTASIR----MDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMF--ENREDRTVK 756
            :.:.|.||...|.    ..|.....:...:...|..:||:..:|.||||.||::  |:....::|
Mouse   614 DLMKGGELLDRILKKKCFSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIK 678

  Fly   757 LIDFGSACYNNRFKSWKDK------PRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVG 815
            :.|||.|      |..:.:      |.||.::..||:|....   |..|.||:.||..|||||.|
Mouse   679 ICDFGFA------KQLRGENGLLLTPCYTANFVAPEVLTQQG---YDAACDIWSLGVLLYTMLAG 734

  Fly   816 HRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDI 880
            :.|:....:|..      .|:..|:..|.|:.....|::.|...:.|:|..|..||..|.|...:
Mouse   735 YTPFSNGPNDTP------EEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYTAEQV 793

  Fly   881 LDSEWL---------QYGSNDPDVDIILPQQMV 904
            |...|:         |..|::|      ||:.|
Mouse   794 LKHPWITQREQLPRHQPNSDEP------PQEAV 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	130/268 (49%)
		STKc_MSK_N	266..533	CDD:270735	131/266 (49%)
		S_TK_X	532..591	CDD:214529	18/59 (31%)
		S_TKc	632..886	CDD:214567	75/265 (28%)
		PKc_like	632..885	CDD:304357	75/264 (28%)
Rps6ka6	NP_080225.2	STKc_RSK_N	193..507	CDD:270734	149/325 (46%)
Rps6ka6	NP_080225.2	STKc_RSK_C	542..828	CDD:270993	84/303 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750