DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JIL-1 and SGK1

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001137148.1	Gene:	SGK1 / 6446	HGNCID:	10810	Length:	526	Species:	Homo sapiens

Alignment Length:	344	Identity:	138/344 - (40%)
Similarity:	205/344 - (59%)	Gaps:	23/344 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 NDFKIIRVLGTGAYGRVFLVRKLTRHDAGKL-YAMKVLNKITVVQKRKTAEHTKTERVVLEAIQR 322
            :||..::|:|.|::|:|.    |.||.|.:: ||:|||.|..:: |:|..:|..:||.||....:
Human   191 SDFHFLKVIGKGSFGKVL----LARHKAEEVFYAVKVLQKKAIL-KKKEEKHIMSERNVLLKNVK 250

  Fly   323 NPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIY 387
            :||||.||::||::.|||.|||:.||||||.||.....|.|.|.|.|.||:..||..||.|.|:|
Human   251 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 315

  Fly   388 RDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWS 452
            ||:|.||||||.:|||||:||||.| ...|:.....:||||.||:|||::...|  :|..||||.
Human   316 RDLKPENILLDSQGHIVLTDFGLCK-ENIEHNSTTSTFCGTPEYLAPEVLHKQP--YDRTVDWWC 377

  Fly   453 VGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGN 517
            :|.:.:|:|.|..||.:.:.......|..:..:.:|.|.:|    ||..:..:|:|:..:|||..
Human   378 LGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS----ARHLLEGLLQKDRTKRLGAK 438

  Fly   518 HRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQ-VP----EDPECDAP 577
            . |..|||.|.||:.|||.:|..|:...|:.|.::..:|:::|..|||:: ||    :.|:....
Human   439 D-DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLV 502

  Fly   578 PSRIR----LFRGYTYVAP 592
            .:.::    .|.|::|..|
Human   503 TASVKEAAEAFLGFSYAPP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	116/269 (43%)
		STKc_MSK_N	266..533	CDD:270735	117/267 (44%)
		S_TK_X	532..591	CDD:214529	18/67 (27%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
SGK1	NP_001137148.1	S_TKc	193..450	CDD:214567	116/269 (43%)
SGK1	NP_001137148.1	STKc_SGK	197..519	CDD:270727	134/334 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910