DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and RPS6KB1

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_003152.1	Gene:	RPS6KB1 / 6198	HGNCID:	10436	Length:	525	Species:	Homo sapiens

Alignment Length:	454	Identity:	172/454 - (37%)
Similarity:	253/454 - (55%)	Gaps:	52/454 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 DGRDPERE----YYDQDMEEDEPNGIEID-ESSSSLSKAKSNNAAAAAAAAAAAAAAAASKASSS 212
            |.||.|.|    .:|.|:::.|..|.|.: |....|:::..:....
Human    15 DFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG------------------- 60

  Fly   213 TTPSYAMPTSNSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFL 277
               .|.:...:....::...:..|               ..|.:....|:::||||.|.||:||.
Human    61 ---PYELGMEHCEKFEISETSVNR---------------GPEKIRPECFELLRVLGKGGYGKVFQ 107

  Fly   278 VRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLV 342
            |||:|..:.||::|||||.|..:|:..|...|||.||.:||.: ::||:|.|.||||:..||||:
Human   108 VRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV-KHPFIVDLIYAFQTGGKLYLI 171

  Fly   343 LDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSD 407
            |::.:|||||..|.....|.|.....|:||:.:||..|||.||||||:|.|||:|:.:||:.|:|
Human   172 LEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTD 236

  Fly   408 FGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDG 472
            |||.|....:... .|:||||:|||||||:...  ||:.||||||:|.|.:::||||.||.   |
Human   237 FGLCKESIHDGTV-THTFCGTIEYMAPEILMRS--GHNRAVDWWSLGALMYDMLTGAPPFT---G 295

  Fly   473 QVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQE 537
            :.::..|. :|.|.:..:|...:..|||.:.|:|::|...|||....||.|::.||||..|||:|
Human   296 ENRKKTID-KILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEE 359

  Fly   538 LRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDA--PPSRIRLFRGYTYVAPEHLEQMR 599
            |..::.:.|:||.|.:|:||..|.::||.|.|.|...|:  ..|..::|.|:|||||..||.::
Human   360 LLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVK 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	126/268 (47%)
		STKc_MSK_N	266..533	CDD:270735	126/266 (47%)
		S_TK_X	532..591	CDD:214529	24/60 (40%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		12/38 (32%)
		TOS motif	28..32		1/3 (33%)
		STKc_p70S6K	94..416	CDD:270736	152/329 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..399		7/18 (39%)
		Autoinhibitory domain	424..525		172/454 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850