Protein Alignment JIL-1 and RPS6KA2

DIOPT Version :10

• Sequence 1: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_006715612.1
• Gene: RPS6KA2 / 6196
• HGNCID: 10431
• Length: 761
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 259/731 - (35%)
• Similarity: 365/731 - (49%)
• Gaps: 80/731 - (10%)

  Fly   180 SSSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDNEAHQRDLEAVT-- 242
            |||||:.:..|..||.......|....|:...:                      |.:.|.|.
Human    26 SSSLSRLEGLNRRAAGIKVVTIADCLHSREPET----------------------QHEEEGVVKE 68

  Fly   243 -DLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKT 306
             |:.::|| ...|....:.|::::|||.|:||:||||||:...|||:|||||||.|.|:  |.:.
Human    69 IDISHHVK-EGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRD 130

  Fly   307 AEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIA 371
            ...:|.||.:|..: .:||:|.||||||:..||||:|||..||:|||.|.....|.|..|:.|:|
Human   131 RVRSKMERDILAEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 194

  Fly   372 EVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEI 436
            |:.|||:.||.|||||||:|.||||||.||||.::|||||| ...:::.||:|||||:||||||:
Human   195 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSK-EAIDHDKRAYSFCGTIEYMAPEV 258

  Fly   437 IRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDF 501
            :..  .||..:.||||.|||.||:|||:.||...|    :.|....|.|.:..:|...|..|:..
Human   259 VNR--RGHTQSADWWSFGVLMFEMLTGSLPFQGKD----RKETMALILKAKLGMPQFLSGEAQSL 317

  Fly   502 VLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTD 566
            :..:.::||..|||.......|||.||||..|:|..|..|..|.|:||.:...:|..:|..|||.
Human   318 LRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTA 382

  Fly   567 QVPEDPECDAPPS--RIRLFRGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPCRP--------- 620
            :.|.|.. ..|||  ...||||:::||...:::..:.:          |..:|..|
Human   383 RTPTDSP-GVPPSANAHHLFRGFSFVASSLIQEPSQQD----------LHKVPVHPIVQQLHGNN 436

  Fly   621 ----DDLELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALISCALDTTNHKNIV 681
                |..|:......|:|..|...|..:||..:..|||..||..|||.   |...|....|.||:
Human   437 IHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEE---IEILLRYGQHPNII 498

  Fly   682 SYHGTFREKCETWIVMEYLSGPELTASI----RMDEDSCREIFLQLVMAVRHIHSKHFIHGDLKP 742
            :....:.:....::|||.:.|.||...|    ...|....::...:...:.::||:..:|.||||
Human   499 TLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKP 563

  Fly   743 ENIMF--ENREDRTVKLIDFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGL 805
            .||::  |:....::::.|||.|............|.||.::..||:|....   |..|.||:.|
Human   564 SNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG---YDAACDIWSL 625

  Fly   806 GATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRD 870
            |..|||||.|..|:....||..      .|:..|:..|.:......|:|.|.|.:.:||..|..|
Human   626 GILLYTMLAGFTPFANGPDDTP------EEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVD 684

  Fly   871 PADRPTLSDILDSEWL 886
            |..|.|...:|...|:
Human   685 PHQRLTAMQVLKHPWV 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	134/266 (50%)
		S_TK_X	532..591	CDD:214529	22/60 (37%)
		S_TKc	632..886	CDD:214567	77/259 (30%)
RPS6KA2	XP_006715612.1	STKc_RSK_N	91..407	CDD:270734	156/326 (48%)
		STKc_RSK3_C	439..731	CDD:271080	80/274 (29%)