DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and rps6ka5

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_693550.4	Gene:	rps6ka5 / 565173	ZFINID:	ZDB-GENE-130530-693	Length:	802	Species:	Danio rerio

Alignment Length:	856	Identity:	307/856 - (35%)
Similarity:	448/856 - (52%)	Gaps:	117/856 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 PLDLDNEAHQRDLEAV------TDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRH 284
            |..::..:.:.||..|      .:|..:|     |.|.:.:|::::||||||||:||||||::.|
Zfish     2 PSTMEGSSGEGDLFTVKHELRNANLTGHV-----ERVGIENFELLKVLGTGAYGKVFLVRKVSGH 61

  Fly   285 DAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGG 349
            |:|||||||||.|.|:|||.||||||:|||.|||.|:::||||:||||||:.:||:|:||:.|||
Zfish    62 DSGKLYAMKVLKKATIVQKAKTAEHTRTERQVLEHIRQSPFLVTLHYAFQTDTKLHLILDYVNGG 126

  Fly   350 ELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKIL 414
            ||||||.....|:|..|.:|..|:|||||.||:|||:|||:||||||||..|||||:||||||
Zfish   127 ELFTHLVQRVRFKEQEVTLYSGEIVLALEHLHKLGIVYRDLKLENILLDSNGHIVLTDFGLSK-- 189

  Fly   415 TAENEY----RAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQ 475
                |:    ||:|.|||:|||||||:..|..|||.||||||:|||.:|||||.|||.....:..
Zfish   190 ----EFHEVERAYSICGTIEYMAPEIVAGGEGGHDKAVDWWSMGVLMYELLTGGSPFTVDGDENS 250

  Fly   476 QSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRT 540
            .|:|:.||.|:.|..|......|:|.:.::|.|:||:|||.....|..:|:|||:..:||::|..
Zfish   251 HSDIAERIMKKDPPFPKDMGPLAKDIIQRLLIKDPKKRLGSGPSGAQNVKKHPFYQKLNWEDLAA 315

  Fly   541 KRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPSRIRLFRGYTYVAPEHL---------- 595
            |:.:||:||.:..|.||.||:.|||:..|.......|.:..|:|:||:::||..|
Zfish   316 KKVRAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPNNCDRIFQGYSFMAPSILFKRNAVMDDP 380

  Fly   596 -----------------EQMRRDNHCEIQYFNTGLQNIPCRPDDLELGTR---TSNGAYGTCHFV 640
                             ..|.:|:...:.|               |:..|   ...|::..|...
Zfish   381 AQLCGGSERPGSAAVARSAMMKDSPFYMNY---------------EMDLRHNALGEGSFSICRQC 430

  Fly   641 VDSSTDLVFLAKIIP--LSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGP 703
            ....|...:..||:.  :......|:.||..|    ..|.|||..|..:.::..|::|:|.|.|.
Zfish   431 THKKTGQKYAVKIVSKRMEAQTQKEIAALKLC----DGHPNIVKLHEIYHDQLHTYLVLELLRGG 491

  Fly   704 ELTASIR----MDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMF-ENREDRTVKLIDFGSA 763
            ||...||    ..|.....|..:||.||.|:|....:|.||||||::| ::.|:..:|:||||.|
Zfish   492 ELLERIRRKQLFSETEASRIMRRLVSAVSHMHDVGVVHRDLKPENLLFTDDTENSEIKIIDFGFA 556

  Fly   764 CYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDH 828
            ............|.:||.||.||:|..:.   |..:.|::.||..|||||.|..|::.....:.|
Zfish   557 RLKPPDNQLLKTPCFTLQYAAPEILKYSG---YDESCDLWSLGVILYTMLSGQVPFQCQGKSLMH 618

  Fly   829 SAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDP 893
            ::|  .|:.:::::|.|:.....|.:.|...:.|:...|..||..|..:..:..:.|||..|...
Zfish   619 TSA--EEIMRKIKQGDFSFEGEAWRNVSSQAKDLIQELLTVDPDKRIKMCGLRYNTWLQDDSQLS 681

  Fly   894 DVDIILPQQM-VVDLSEDTMEQPTGGMFDDQQQLEF---MHDKS--AEDEGITLVSEPMDTTVAT 952
            ...::.|..: ...:|..:..:.|...|:..::..|   ..||:  |:...:...|...||..::
Zfish   682 SNPLMTPDILGSSTISVHSCVKATFNAFNKCKREGFRLQTVDKAPLAKRRKMKKTSTSTDTRSSS 746

  Fly   953 HESRRNAAAFSSVVAPT-TDDEIVHERFDPAFEVQADFYGFDENAPPLPLPEEYYSELPL---PE 1013
            .||..::::.|.....| ||.|:.                   |.|..|:      ..||   |:
Zfish   747 SESTHSSSSSSQSQDKTPTDGEMA-------------------NLPQAPV------STPLTLGPD 786

  Fly  1014 EDRQYIPPPPA 1024
            ::.....|.||
Zfish   787 DEPSQGEPQPA 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	160/272 (59%)
		STKc_MSK_N	266..533	CDD:270735	160/270 (59%)
		S_TK_X	532..591	CDD:214529	22/58 (38%)
		S_TKc	632..886	CDD:214567	77/260 (30%)
		PKc_like	632..885	CDD:304357	77/259 (30%)
rps6ka5	XP_693550.4	PKc_like	37..367	CDD:304357	183/335 (55%)
		S_TKc	38..304	CDD:214567	159/271 (59%)
		PKc_like	405..714	CDD:304357	88/332 (27%)
		S_TKc	419..663	CDD:214567	76/252 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573228
Domainoid	1	1.000	348	1.000	Domainoid score	I998
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48302
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1286
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104032
Panther	1	1.100	-	-	O	PTHR24351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.760