DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and rps6ka4

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_005165672.1	Gene:	rps6ka4 / 561959	ZFINID:	ZDB-GENE-060526-284	Length:	786	Species:	Danio rerio

Alignment Length:	795	Identity:	315/795 - (39%)
Similarity:	440/795 - (55%)	Gaps:	89/795 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 TSNSTPLDLDNEAHQRDLEAVTDLKYYVKLYS----DEAVSLNDFKIIRVLGTGAYGRVFLVRKL 281
            :|.|:..|.|.|..::    |..:|:.:...:    .|.|.:.:|::::||||||||:||||||:
Zfish     5 SSGSSGEDSDRETRRK----VCTVKHEITNANLTGYTEKVGMENFELLKVLGTGAYGKVFLVRKI 65

  Fly   282 TRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFA 346
            :.||.|||||||||.|..:|||.||||||:|||.|||.|:::||||:||||||:.:||:|:||:.
Zfish    66 SGHDKGKLYAMKVLKKAAIVQKAKTAEHTRTERQVLEHIRQSPFLVTLHYAFQTQTKLHLILDYV 130

  Fly   347 NGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLS 411
            :|||:|||||..::|.|..||:|:.|::||||.||:|||:||||||||||||.:||:||:|||||
Zfish   131 SGGEMFTHLYQRDHFSEDEVRIYVGEIILALEHLHKLGIVYRDIKLENILLDSDGHVVLTDFGLS 195

  Fly   412 KILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQ 476
            |....|.:.|.:|||||:||||||||| |..||..||||||:|:|.||||||||||.....:..|
Zfish   196 KEFLEEEKERTYSFCGTIEYMAPEIIR-GKSGHGKAVDWWSLGILMFELLTGASPFTLEGERNSQ 259

  Fly   477 SEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTK 541
            ||:|:||.:.:|..||.....|:|.:.|::.|:|.:|||...|.|.|||.||||.|:||.:|..|
Zfish   260 SEVSKRILRCEPPFPSIIGPLAQDLLRKLIVKDPHKRLGSGPRGAEEIKGHPFFKGLNWSDLAEK 324

  Fly   542 RRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPSRIRLFRGYTYVAPEHLEQMR------R 600
            :.::|::|.|..|.||.||:.|||...|.......|||..|||:||::|||..|....      .
Zfish   325 KVQSPFRPELRDELDVGNFAEEFTGMEPVYSPASTPPSTDRLFQGYSFVAPSILFNKNVVMADVL 389

  Fly   601 DNHCEI--------------------QYFNTGLQNIPCRPDDLELGTRTSNGAYGTCHFVVDSST 645
            |.|..:                    |::...||..|       ||    .|::..|.......:
Zfish   390 DAHVNVDRPGSATVQRSAMLKESQFFQHYELCLQGSP-------LG----EGSFSVCRKCRHKQS 443

  Fly   646 DLVFLAKIIP--LSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTAS 708
            ...:..||:.  :......|:.||..|    .:|.|||:.|..:.::..|::|||.|.|.||...
Zfish   444 GQEYAVKIVSRRMEAMTQREIAALRQC----ESHPNIVTLHEVYTDQYHTYLVMEMLRGGELLER 504

  Fly   709 IR----MDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMFENREDRTV-KLIDFGSACYNNR 768
            ||    ..|....::...||.||.::|....:|.||||||::|.:..|.:| |:||||.|   ..
Zfish   505 IRKRKMFAEWEASQLMKSLVSAVSYMHEAGVVHRDLKPENVLFADESDESVLKVIDFGFA---RL 566

  Fly   769 FKSWK-----DKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDH 828
            |.:..     ..|.:||.||.||:...:.   |..|.|::.||..|||||.|..|::..:..:..
Zfish   567 FPAGSGSAPLQTPCFTLQYAAPELFHSSG---YDQACDLWSLGVILYTMLSGQVPFQSEKKVMTS 628

  Fly   829 SAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDP 893
            |.||  ::..:::.|.|:.....|:..|...:.||...|..||..|..||.:.::.|||.|....
Zfish   629 SHAA--DIMHKIKEGDFSLDGEAWKGVSEEAKDLVRGLLTVDPERRLKLSALKENAWLQGGGVMS 691

  Fly   894 DVDIILPQQMVVDLSEDTMEQPTGGMFDDQQQLEFMHDKSAEDEGITLVS---------EPMDTT 949
            ...:..|     |:.|.|  .||...:.:.....|...|.   ||..|.|         ..|..|
Zfish   692 STPLCTP-----DVLEST--GPTVRTYVNATYKAFNRGKR---EGFFLKSVDNAPLAKRRKMKMT 746

  Fly   950 VATHESRRNAAAFSS 964
            ....|:||::::.||
Zfish   747 STGVETRRSSSSSSS 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	164/268 (61%)
		STKc_MSK_N	266..533	CDD:270735	165/266 (62%)
		S_TK_X	532..591	CDD:214529	25/58 (43%)
		S_TKc	632..886	CDD:214567	80/265 (30%)
		PKc_like	632..885	CDD:304357	80/264 (30%)
rps6ka4	XP_005165672.1	STKc_MSK2_N	44..375	CDD:270765	192/331 (58%)
		S_TKc	45..313	CDD:214567	164/268 (61%)
		STKc_MSK2_C	414..724	CDD:271082	97/339 (29%)
		S_TKc	418..684	CDD:214567	85/288 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573229
Domainoid	1	1.000	348	1.000	Domainoid score	I998
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1286
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104032
Panther	1	1.100	-	-	LDO	PTHR24351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.760