Protein Alignment JIL-1 and PRKACA

DIOPT Version :10

• Sequence 1: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_001291278.1
• Gene: PRKACA / 5566
• HGNCID: 9380
• Length: 427
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 117/312 - (37%)
• Similarity: 188/312 - (60%)
• Gaps: 17/312 - (5%)

  Fly   258 LNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQR 322
            |:.|:.|:.||||::|||.||:   ..:.|..||||:|:|..|| |.|..|||..|:.:|:|: .
Human   117 LDQFERIKTLGTGSFGRVMLVK---HKETGNHYAMKILDKQKVV-KLKQIEHTLNEKRILQAV-N 176

  Fly   323 NPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIY 387
            .||||.|.::|:.:|.||:|:::..|||:|:||.....|.|...|.|.|::||..|.||.|.:||
Human   177 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 241

  Fly   388 RDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWS 452
            ||:|.||:|:|.:|:|.::|||.:|.:..    |..:.|||.||:|||||.:  .|::.|||||:
Human   242 RDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILS--KGYNKAVDWWA 300

  Fly   453 VGVLTFELLTGASP-FATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGG 516
            :|||.:|:..|..| ||....|:.:..:|.:::     .||.||::.:|.:..:|:.:..:|.|.
Human   301 LGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR-----FPSHFSSDLKDLLRNLLQVDLTKRFGN 360

  Fly   517 NHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQV 568
            .....::||.|.:|...:|..:..::.:||:.|......|..||.:...:::
Human   361 LKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	107/267 (40%)
		S_TK_X	532..591	CDD:214529	7/37 (19%)
		S_TKc	632..886	CDD:214567
PRKACA	NP_001291278.1	STKc_PKA	118..407	CDD:271111	116/304 (38%)