DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and akt2

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_937789.1	Gene:	akt2 / 378972	ZFINID:	ZDB-GENE-031007-5	Length:	479	Species:	Danio rerio

Alignment Length:	409	Identity:	156/409 - (38%)
Similarity:	224/409 - (54%)	Gaps:	51/409 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 AAAAAAAASKASSSTTP---SYAMPTSNSTPLDLDNEAHQRDLE----AVTDLKYYVKLYSDEAV 256
            |..|.|...|:.....|   ::..|..||             ||    |:|.        |...|
Zfish   102 AIQAVANGLKSREEDEPMDINFGSPGDNS-------------LEGMEAAITK--------SRTKV 145

  Fly   257 SLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQ 321
            :::||..:::||.|.:|:|.|||:..   .|..||||:|.|..::.|.:.| ||.||..||:. .
Zfish   146 TMSDFDYLKLLGKGTFGKVILVREKA---TGMYYAMKILRKEVIIAKDEVA-HTITESRVLQN-T 205

  Fly   322 RNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGII 386
            |:|||.:|.||||:..:|..|:::|||||||.||.....|.|.|.|.|.||:|.|||.||...::
Zfish   206 RHPFLTTLKYAFQTRDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSKDVV 270

  Fly   387 YRDIKLENILLDGEGHIVLSDFGLSKI-LTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDW 450
            |||:||||::||.:|||.::||||.|. :|  ||....:||||.||:|||::.....|.  ||||
Zfish   271 YRDLKLENLMLDKDGHIKITDFGLCKEGIT--NEATMKTFCGTPEYLAPEVLEDNDYGR--AVDW 331

  Fly   451 WSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLG 515
            |.:||:.:|::.|..||...|    ...:...|..|:...|.:.|..|:..:..:|:|:||:|||
Zfish   332 WGLGVVMYEMMCGRLPFYNQD----HERLFELILMEEIRFPRNLSPEAKALLAGLLKKDPKQRLG 392

  Fly   516 GNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQ----VPEDP---- 572
            |...||.|:..|.|||.:|||::..|:...|:||.:|:|.|.:.|.:|||.|    .|.|.
Zfish   393 GGPEDAKEVMTHKFFNNMNWQDVLQKKLVPPFKPQVTSETDTRYFDDEFTAQTITVTPPDQYDSL 457

  Fly   573 ECDAPPSRIRLFRGYTYVA 591
            :.:.|.:|.. |..::|.|
Zfish   458 DAEDPDTRTH-FSQFSYSA 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	116/269 (43%)
		STKc_MSK_N	266..533	CDD:270735	118/267 (44%)
		S_TK_X	532..591	CDD:214529	21/66 (32%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
akt2	NP_937789.1	PH_PKB	4..111	CDD:269947	3/8 (38%)
		PH	6..106	CDD:278594	1/3 (33%)
		S_TKc	150..407	CDD:214567	116/269 (43%)
		STKc_PKB_beta	154..476	CDD:173686	140/336 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910