DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and Rps6ka4

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001101987.2	Gene:	Rps6ka4 / 361715	RGDID:	1307277	Length:	773	Species:	Rattus norvegicus

Alignment Length:	750	Identity:	302/750 - (40%)
Similarity:	408/750 - (54%)	Gaps:	75/750 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 DEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVL 317
            :|.||:.:|.:::||||||||:||||||...||||||||||||.|..:||:.||.|||:|||.||
  Rat    25 EEKVSVENFALLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVL 89

  Fly   318 EAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQ 382
            |.:::.||||:||||||:.:||:|:||:.:|||:|||||..:.|:|:.||||..|:|||||.||:
  Rat    90 ELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHK 154

  Fly   383 LGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSA 447
            |||||||:||||:|||.||||||:||||||....|.:.|..|||||:|||||||||: ..||..|
  Rat   155 LGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRS-KAGHGKA 218

  Fly   448 VDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKR 512
            |||||:|:|.||||||||||.....:..|:|:||||.|..|..|......|:|.:.::|.|:||:
  Rat   219 VDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKK 283

  Fly   513 RLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVP-EDPECDA 576
            |||...:.|.|:|.|.||.|::|..|..::..||::|.:.:|.||.||:.|||...| ..|....
  Rat   284 RLGAGPQGAQEVKSHLFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPAGSP 348

  Fly   577 PPSRIRLFRGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPCRP--------------------- 620
            ||...|:|:||::|||..|          ..:.|..:.::...|
  Rat   349 PPGDPRIFQGYSFVAPSIL----------FDHNNAVMADVLAAPGAGYRPGRAAVARSAMMQDSP 403

  Fly   621 --DDLELGTR---TSNGAYGTCHFVVDSSTDLVFLAKIIP--LSKFRPSEVDALISCALDTTNHK 678
              ...||..|   ...|::..|.......:...|..||:.  |.:....||.||..|    .:|.
  Rat   404 FFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEENTQREVAALRLC----QSHP 464

  Fly   679 NIVSYHGTFREKCETWIVMEYLSGPELTASIR----MDEDSCREIFLQLVMAVRHIHSK-HFIHG 738
            |:|:.|....::..|::|:|.|.|.||...||    ..|....:|...||.||..:|.: ..:|.
  Rat   465 NVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHR 529

  Fly   739 DLKPENIMF-ENREDRTVKLIDFGSACYNNRFKSWK-----DKPRYTLDYAPPEMLADANLVTYS 797
            |||||||:: ::.....||:||||.|    |.:...     ..|.:||.||.||:||...   |.
  Rat   530 DLKPENILYADDTPGAPVKIIDFGFA----RLRPQSPAGPMQTPCFTLQYAAPELLAQQG---YD 587

  Fly   798 PAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHL 862
            .:.|::.||..||.||.|..|::........|.||  |:..::|.|.|:.....|:..|...:.|
  Rat   588 ESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAA--EIMCKIREGRFSLDGEAWQGVSEEAKEL 650

  Fly   863 VSWCLQRDPADRPTLSDILDSEWLQYGSNDPDVDIILPQQMVVDLSEDTMEQPTGGMFDDQQQLE 927
            |...|..|||.|..|..:..|.|||.||......:..|     |:.|.:......|:     ...
  Rat   651 VRGLLTVDPAKRLKLEGLRSSSWLQDGSARSSPPLRTP-----DVLESSGPAVRSGL-----NAT 705

  Fly   928 FMHDKSAEDEGITLVS-EPMDTTVATHESRRNAAA 961
            ||.....:.||..|.| |.........:..|:|||
  Rat   706 FMAFNRGKREGFFLKSVENAPLAKRRKQKLRSAAA 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	162/268 (60%)
		STKc_MSK_N	266..533	CDD:270735	163/266 (61%)
		S_TK_X	532..591	CDD:214529	22/59 (37%)
		S_TKc	632..886	CDD:214567	84/266 (32%)
		PKc_like	632..885	CDD:304357	84/265 (32%)
Rps6ka4	NP_001101987.2	STKc_MSK2_N	32..364	CDD:270765	187/332 (56%)
Rps6ka4	NP_001101987.2	PKc_like	404..714	CDD:419665	98/332 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334257
Domainoid	1	1.000	361	1.000	Domainoid score	I924
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1139
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104032
Panther	1	1.100	-	-	LDO	PTHR24351
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.760