DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and sgk1

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_005162356.1	Gene:	sgk1 / 324140	ZFINID:	ZDB-GENE-030131-2860	Length:	598	Species:	Danio rerio

Alignment Length:	445	Identity:	161/445 - (36%)
Similarity:	236/445 - (53%)	Gaps:	42/445 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 YYDQDMEEDEPNGIEIDESSSSLSKAKS---NNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTS 222
            ||..|.|.|     ....|.::..|.:.   |:.....:|.:.|......::..:.||...:...
Zfish   177 YYHGDPESD-----YCCSSDTTFMKQRKMGLNDFIQKLSANSYACKHPEVQSILNLTPPQDVELM 236

  Fly   223 NSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAG 287
            ||.|....:.:.|.:|..          .|:.....:||..::|:|.|::|:|.|.|.  |.|.
Zfish   237 NSNPSPPPSPSQQINLGP----------SSNPTAKPSDFDFLKVIGKGSFGKVLLARH--RSDE- 288

  Fly   288 KLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELF 352
            |.||:|||.|..:: |:|..:|..:||.||....::||||.|||:||::.|||.|||:.||||||
Zfish   289 KFYAVKVLQKKAIL-KKKEEKHIMSERNVLLKNVKHPFLVGLHYSFQTTDKLYFVLDYINGGELF 352

  Fly   353 THLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAE 417
            .||.....|.|.|.|.|.||:..||..||.|.|:|||:|.||||||.:|||:|:||||.| ...|
Zfish   353 YHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIILTDFGLCK-ENIE 416

  Fly   418 NEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRR 482
            ......:||||.||:|||::...|  :|..||||.:|.:.:|:|.|..||.:.:    .:|:...
Zfish   417 PNGTTSTFCGTPEYLAPEVLHKQP--YDRTVDWWCLGAVLYEMLYGLPPFYSRN----TAEMYDN 475

  Fly   483 IQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPY 547
            |..:...:..:.|..||..:..:|:|:..:|||... |.:|||.|.||:.|||.:|..|:...|:
Zfish   476 ILNKPLQLKPNISNAARHLLEGLLQKDRTKRLGFTD-DFTEIKNHMFFSPINWDDLNAKKLTPPF 539

  Fly   548 KPTLTAEDDVQNFSNEFTDQ-VPEDPECDAPPSRI---------RLFRGYTYVAP 592
            .|.:|..:|:::|..||||: ||....| :|.|.:         ..|.|::| ||
Zfish   540 NPNVTGPNDLRHFDPEFTDEPVPNSIGC-SPDSALVTSSITEATEAFLGFSY-AP 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	116/268 (43%)
		STKc_MSK_N	266..533	CDD:270735	117/266 (44%)
		S_TK_X	532..591	CDD:214529	22/68 (32%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
sgk1	XP_005162356.1	STKc_SGK1	257..595	CDD:270753	143/350 (41%)
sgk1	XP_005162356.1	S_TKc	265..522	CDD:214567	116/268 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910