Protein Alignment JIL-1 and RPS6KA6

DIOPT Version :10

• Sequence 1: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_016884912.1
• Gene: RPS6KA6 / 27330
• HGNCID: 10435
• Length: 762
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 246/682 - (36%)
• Similarity: 354/682 - (51%)
• Gaps: 60/682 - (8%)

  Fly   261 FKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPF 325
            |::::|||.|::|:||||||.|..|||:|||||||.|.::  |.:....||.||.:|..: .:||
Human    90 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL--KVRDRVRTKMERDILVEV-NHPF 151

  Fly   326 LVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDI 390
            :|.||||||:..||||:|||..||::||.|.....|.|..|:.|:||:.|||:.||||||:|||:
Human   152 IVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDL 216

  Fly   391 KLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGV 455
            |.||||||..|||.|:|||||| .:.:.|.:|:|||||:||||||::..  .||..:.||||.||
Human   217 KPENILLDEIGHIKLTDFGLSK-ESVDQEKKAYSFCGTVEYMAPEVVNR--RGHSQSADWWSYGV 278

  Fly   456 LTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRD 520
            |.||:|||..||...|    ::|....|.|.:..:|...||.|:..:..:.::||..|||.  ..
Human   279 LMFEMLTGTLPFQGKD----RNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EG 337

  Fly   521 ASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPED-PECDAPPSRIRLF 584
            ..|||.|.||..|:|.:|..:..:.|:||.....||...|..|||.:.|:| |...|..:..:||
Human   338 VEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLF 402

  Fly   585 RGYTYVAPEHLEQMR-----RDNHCEIQYFNTGLQNIPCRPDDLELGTRTSNGAYGTCHFVVDSS 644
            :|:::||....|:.:     ..|...|...|   .|.....:..||......|:|..|...:.::
Human   403 KGFSFVATSIAEEYKITPITSANVLPIVQIN---GNAAQFGEVYELKEDIGVGSYSVCKRCIHAT 464

  Fly   645 TDLVFLAKIIPLSKFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASI 709
            |::.|..|||..||..|||.   |...:....|.||::....|.:....::|.:.:.|.||...|
Human   465 TNMEFAVKIIDKSKRDPSEE---IEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRI 526

  Fly   710 R----MDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMF--ENREDRTVKLIDFGSACYNNR 768
            .    ..|....:|...:...|.::|.:..:|.||||.||::  |:....::::.|||.|
Human   527 LKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFA----- 586

  Fly   769 FKSWKDK------PRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVD 827
             |..:.:      |.||.::..||:|....   |..|.||:.||...||||.|:.|:....:|..
Human   587 -KQLRGENGLLLTPCYTANFVAPEVLMQQG---YDAACDIWSLGVLFYTMLAGYTPFANGPNDTP 647

  Fly   828 HSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSND 892
                  .|:..|:..|.|:.....|::.|...:.|:|..|..||..|.|...||...|:.:....
Human   648 ------EEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQL 706

  Fly   893 P-------DVDIILPQQMVVDLSEDTME--QP 915
            |       ||..::...||...|..|.:  ||
Human   707 PNDQPKRNDVSHVVKGAMVATYSALTHKTFQP 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	133/266 (50%)
		S_TK_X	532..591	CDD:214529	19/59 (32%)
		S_TKc	632..886	CDD:214567	74/265 (28%)
RPS6KA6	XP_016884912.1	STKc_RSK_N	94..408	CDD:270734	152/325 (47%)
		STKc_RSK4_C	438..732	CDD:271079	83/311 (27%)