Protein Alignment JIL-1 and LATS2

DIOPT Version :10

• Sequence 1: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 166/597 - (27%)
• Similarity: 243/597 - (40%)
• Gaps: 158/597 - (26%)

  Fly   128 SPPTPPSPPTTNVADIVCISDAESE--------------------DGRDP------------ERE 160
            :|...|:|.....|:.:   ||:.|                    |.|.|            :.|
Human   470 APAPAPAPAPAPAAEGL---DAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSE 531

  Fly   161 YYDQD-----MEE------DEPNGIEIDESSSSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTT 214
            .||.|     ||:      :||.|.:....|:...|...:......:.......:...:...|..
Human   532 QYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRI 596

  Fly   215 PSYA---------MPTSN---------STPLDLDN--------EAHQRDLEAVTDLKYYVKLYSD 253
            .||:         ....|         :..|.|:.        ||.|..:..:        ||..
Human   597 KSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKI--------LYQK 653

  Fly   254 EA---------VSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEH 309
            |:         :..:.|..|:.||.||:|.|.|..|:..|   .|||||.|.|..|:.:.:.| |
Human   654 ESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTH---ALYAMKTLRKKDVLNRNQVA-H 714

  Fly   310 TKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVV 374
            .|.||.:| |...|.::|.|:|:||....||.|:|:..||::.:.|...|.|.|...|.||||:.
Human   715 VKAERDIL-AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELT 778

  Fly   375 LALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGL----------------------------- 410
            ||:|.:|::|.|:||||.:|||:|.:|||.|:||||
Human   779 LAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDL 843

  Fly   411 ----------SKILTAENEYR-------AHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTF 458
                      .::.|.|...|       |||..||..|:|||::..  .|:....|||||||:.|
Human   844 WDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLR--KGYTQLCDWWSVGVILF 906

  Fly   459 ELLTGASPFATSDGQVQQSEISRRIQKEQPM-IPS--SFSANARDFVLKMLEKNPKRRLGGNHRD 520
            |:|.|..||........|.::   |..|..: ||:  ..|..|||.:.|:. .:...|||.|  .
Human   907 EMLVGQPPFLAPTPTETQLKV---INWENTLHIPAQVKLSPEARDLITKLC-CSADHRLGRN--G 965

  Fly   521 ASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPED-PECDAPPSRIRLF 584
            |.::|.||||:.|::.. ..:::.|||.||::...|..||     |.|.|: |..||.....:.:
Human   966 ADDLKAHPFFSAIDFSS-DIRKQPAPYVPTISHPMDTSNF-----DPVDEESPWNDASEGSTKAW 1024

  Fly   585 RGYTYVAPEHLE 596
            ...|....:|.|
Human  1025 DTLTSPNNKHPE 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	113/315 (36%)
		S_TK_X	532..591	CDD:214529	16/59 (27%)
		S_TKc	632..886	CDD:214567
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581
		PHA03247	<143..521	CDD:223021	10/53 (19%)
		MobB_LATS2	587..669	CDD:439272	12/89 (13%)
		STKc_LATS2	668..1048	CDD:173715	133/388 (34%)