DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JIL-1 and Akt1

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_150233.1	Gene:	Akt1 / 24185	RGDID:	2081	Length:	480	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	133/328 - (40%)
Similarity:	198/328 - (60%)	Gaps:	21/328 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 VSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAI 320
            |::|:|:.:::||.|.:|:|.||::..   .|:.||||:|.|..:|.|.:.| ||.||..||:.
  Rat   145 VTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVA-HTLTENRVLQN- 204

  Fly   321 QRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLH-QLG 384
            .|:|||.:|.|:||:..:|..|:::|||||||.||.....|.|.|.|.|.||:|.||:.|| :..
  Rat   205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269

  Fly   385 IIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVD 449
            ::|||:||||::||.:|||.::||||.| ...::.....:||||.||:|||::.....|.  |||
  Rat   270 VVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDGATMKTFCGTPEYLAPEVLEDNDYGR--AVD 331

  Fly   450 WWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRL 514
            ||.:||:.:|::.|..||...|    ..::...|..|:...|.:....|:..:..:|:|:|.:||
  Rat   332 WWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRL 392

  Fly   515 GGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQV----PEDP--- 572
            ||...||.||.:|.||..|.||::..|:...|:||.:|:|.|.:.|..|||.|:    |.|.
  Rat   393 GGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDS 457

  Fly   573 -EC 574
             ||
  Rat   458 MEC 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	110/269 (41%)
		STKc_MSK_N	266..533	CDD:270735	111/267 (42%)
		S_TK_X	532..591	CDD:214529	19/51 (37%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
Akt1	NP_150233.1	PH_PKB	4..111	CDD:269947
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	14..19
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	23..25
		STKc_PKB_alpha	124..479	CDD:270746	133/328 (41%)
		Inhibitor binding. /evidence=ECO:0000250	228..230		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..480		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910