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Protein Alignment JIL-1 and AKT2

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001617.1	Gene:	AKT2 / 208	HGNCID:	392	Length:	481	Species:	Homo sapiens

Alignment Length:	464	Identity:	157/464 - (33%)
Similarity:	233/464 - (50%)	Gaps:	62/464 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 YRETISPPTPPSPPTTNVADIVCISDAESEDGRDPEREYY-----------DQDMEEDEPNGIEI 176
            |:|....|....||..|.:    :::.:......|....:           ::....|.|:  |.
Human    38 YKERPEAPDQTLPPLNNFS----VAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPD--ER 96

  Fly   177 DESSSSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDNEAHQRDLEAV 241
            :|...::... :|:....|...........|.:.||||....:..|.:.
Human    97 EEWMRAIQMV-ANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKAR---------------- 144

  Fly   242 TDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKT 306
                        ..|::|||..:::||.|.:|:|.|||:..   .|:.||||:|.|..::.|.:.
Human   145 ------------AKVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVIIAKDEV 194

  Fly   307 AEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIA 371
            | ||.||..||:. .|:|||.:|.||||:..:|..|:::|||||||.||.....|.|.|.|.|.|
Human   195 A-HTVTESRVLQN-TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGA 257

  Fly   372 EVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEI 436
            |:|.|||.||...::||||||||::||.:|||.::||||.|...::.. ...:||||.||:|||:
Human   258 EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGA-TMKTFCGTPEYLAPEV 321

  Fly   437 IRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDF 501
            :.....|.  |||||.:||:.:|::.|..||...|    ...:...|..|:...|.:.|..|:..
Human   322 LEDNDYGR--AVDWWGLGVVMYEMMCGRLPFYNQD----HERLFELILMEEIRFPRTLSPEAKSL 380

  Fly   502 VLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTD 566
            :..:|:|:||:||||...||.|:.||.||..||||::..|:...|:||.:|:|.|.:.|.:|||.
Human   381 LAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTA 445

  Fly   567 Q----VPED 571
            |    .|.|
Human   446 QSITITPPD 454

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.