Protein Alignment JIL-1 and Rps6ka2

DIOPT Version :10

• Sequence 1: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_035429.1
• Gene: Rps6ka2 / 20112
• MGIID: 1342290
• Length: 733
• Species: Mus musculus
• Alignment Length: 709
• Identity: 257/709 - (36%)
• Similarity: 368/709 - (51%)
• Gaps: 73/709 - (10%)

  Fly   222 SNSTPLD-LDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHD 285
            |.|:.|. |:.|...:::    |:..:|| ...|....:.|::::|||.|:||:||||||:|..|
Mouse    24 SKSSSLSRLEEEGIVKEI----DISNHVK-EGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSD 83

  Fly   286 AGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGE 350
            ||:|||||||.|.|:  |.:....:|.||.:|..: .:||:|.||||||:..||||:|||..||:
Mouse    84 AGQLYAMKVLKKATL--KVRDRVRSKMERDILAEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGD 145

  Fly   351 LFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILT 415
            |||.|.....|.|..|:.|:||:.|||:.||.|||||||:|.||||||.||||.::||||||..|
Mouse   146 LFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEAT 210

  Fly   416 AENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEIS 480
             :::.||:|||||:||||||::..  .||..:.||||.|||.||:|||:.||...|    :.|..
Mouse   211 -DHDKRAYSFCGTIEYMAPEVVNR--RGHTQSADWWSFGVLMFEMLTGSLPFQGKD----RKETM 268

  Fly   481 RRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKA 545
            ..|.|.:..:|...||.|:..:..:.::||..|||.......|||.||||..|:|.:|..|..|.
Mouse   269 ALILKAKLGMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTIDWNKLYRKEIKP 333

  Fly   546 PYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPS--RIRLFRGYTYVAPEHLEQMRRDNHCEIQY 608
            |:||.:...:|..:|..|||.:.|.|.. ..|||  ...||||:::||...:::..:
Mouse   334 PFKPAVGRPEDTFHFDPEFTARTPTDSP-GVPPSANAHHLFRGFSFVASSLVQEPSQ-------- 389

  Fly   609 FNTGLQNIPCRP----------------DDLELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLS 657
                 |::|..|                |..|:......|:|..|...|..:||..:..|||..|
Mouse   390 -----QDVPKAPIHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKS 449

  Fly   658 KFRPSEVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASIR----MDEDSCRE 718
            |..|||.   |...|....|.||::....:.:....::|||.:.|.||...|.    ..|....:
Mouse   450 KRDPSEE---IEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASD 511

  Fly   719 IFLQLVMAVRHIHSKHFIHGDLKPENIMF--ENREDRTVKLIDFGSACYNNRFKSWKDKPRYTLD 781
            :...:...:.::||:..:|.||||.||::  |:....::::.|||.|............|.||.:
Mouse   512 VLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 576

  Fly   782 YAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFN 846
            :..||:|....   |..|.|::.||..|||||.|..|:....||..      .|:..|:..|.:.
Mouse   577 FVAPEVLKRQG---YDAACDVWSLGILLYTMLAGFTPFANGPDDTP------EEILARIGSGKYA 632

  Fly   847 QRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWL---QYGSND----PDVDII 898
            .....|:|.|.|.:.:||..|..||..|.|...:|...|:   :|.|.:    .||.::
Mouse   633 LSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWIVNREYLSQNQLSRQDVHLV 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	137/266 (52%)
		S_TK_X	532..591	CDD:214529	22/60 (37%)
		S_TKc	632..886	CDD:214567	76/259 (29%)
Rps6ka2	NP_035429.1	STKc_RSK_N	63..379	CDD:270734	159/326 (49%)
		STKc_RSK3_C	411..703	CDD:271080	83/293 (28%)