DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and rskd-1

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_506082.2	Gene:	rskd-1 / 179685	WormBaseID:	WBGene00010096	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	1022	Identity:	183/1022 - (17%)
Similarity:	324/1022 - (31%)	Gaps:	379/1022 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRLQKQNY-----------EILSGTSTSRLKNHQHPRESESLAYEEPDQMVRNHLNGQLVANGN 54
            :|:|.||.|           :::..:..|.::..:|..|: .|.:....:::|
Worm    87 ISKLHKQLYLRGTFPVFPPGKLIGSSDPSVIQERRHAIEA-CLNFVFDSEVLR------------ 138

  Fly    55 GKTRKNSNSETMTNGKKSKLNTEGSGSGSGKTLNYNNNNNNNNSISATNGQYTNSSS-----KTT 114
                            ||:|..|.......||  |..:....|.:.     |.||||     .|.
Worm   139 ----------------KSRLLHEFVEKAKEKT--YTAHEITGNEVF-----YDNSSSILDQPNTN 180

  Fly   115 SASARDYTYRETISPPTPPSPPTTNVADIVCISDAESEDGRDPEREYYDQDMEEDEP-------N 172
            |:.:....:...:.|....:.......|:...|:..:|:.|...:    ..|:...|       :
Worm   181 SSDSDSPNHAALLEPTHEQTGDDFQFPDVAIASETSNEEQRTARK----SSMKRLFPRLRGSTHH 241

  Fly   173 GIEIDESSSSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDNEAHQRD 237
            .|||:|:.:..........|.|..|....|...|.:...|...|...      .:.::::..:|:
Worm   242 NIEIEETPADYLVTAGQLVATAQRAEEEHAYELAFQCYKSAASSLIQ------GVHIESDMTKRN 300

  Fly   238 LEAVTDLKYYV---KLYS-----DEAV------------------------SLNDFKIIRVL-GT 269
            .......||.|   |||.     |.:|                        |:.:::.|.|| ..
Worm   301 AVRRKTAKYLVKAEKLYRTYLSLDGSVFNFEGLLTAAMQDPNILAFQCSNKSMKNYRFIGVLPEL 365

  Fly   270 GAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQ 334
            .|..:|.||.: |..::.|.|.||::.|  .|.....:....|         ..|.:|.|...|:
Worm   366 DAERKVILVEE-TIGESNKKYVMKLIEK--GVPSSDCSIFLPT---------NIPHMVQLVQFFE 418

  Fly   335 SSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDG 399
            :.:.:.|:|:|...|:|::.|....:..|||..:::||             :..|::      ||
Worm   419 TETHIILLLEFVEPGQLWSFLRRMFDEAESRHVLWLAE-------------LKADVR------DG 464

  Fly   400 EGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGA 464
            :
Worm   465 D---------------------------------------------------------------- 465

  Fly   465 SPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPF 529
                      ..||::.:|.|.:                            ||:|....:    |
Worm   466 ----------TTSEVTVQITKNE----------------------------GNYRGRRLL----F 488

  Fly   530 FNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEF-TDQ-----VPEDP--ECDAPPSRIRLFRG 586
            ..|::::.:...|.              ::||:|. :|:     |.|||  ..|||.....:...
Worm   489 TVGVDYERVVEMRD--------------ESFSSEKPSDESLLCTVGEDPTGRSDAPTGDFTIAGN 539

  Fly   587 YTYVAPEHLEQMRRDNHCEIQY-FNTGLQNIPCRPDDLELGTRTSNGAYGTCHFVVDSSTDLVFL 650
            ....|..|..|:..::...::: |::.....|       .|.|.|:          ::.......
Worm   540 SREAAESHYFQVEEESPAAVKFDFSSSKSQSP-------RGNRISS----------ENQNHSPSS 587

  Fly   651 AKIIPLSKFRPSEVDALISCALDTTNHKNI-----------VSYHGTFREKCETWIVMEYLSGPE 704
            :|::.|.             :.|::|.|.:           |....:.|.:     |..||..||
Worm   588 SKVVKLD-------------SADSSNSKEMFLKNLWKALQTVQKQLSLRRR-----VWNYLDLPE 634

  Fly   705 LTASIRMDEDSCREIFLQLVMAVRHIHSKH--FIHGDLKPENIMFENREDRTVKLIDFGSACYNN 767
               |:.:...:      |:|.....:|::|  || ||...::|:.::  |..:.:...|.....|
Worm   635 ---SLIVHWSA------QIVSFFFVLHAEHHEFI-GDFNADDILIDS--DGNLLMTYIGRWYETN 687

  Fly   768 RFKSWKDKPRYTLDYAPPEMLADANLVTY----SPAVDIYGLGATLYTMLVGHRPYRQNEDDVDH 828
            |.|      |.|..|:.||.      ..|    :|..||:.|||.|:.||.|...         .
Worm   688 RRK------RLTDGYSAPES------SQYGWEPTPESDIWTLGALLFEMLCGRSL---------A 731

  Fly   829 SAAAHHELRKRMRRGTFNQRSMRWESASPAF--RHLVSWCLQRDPADRPTLSDI------LDSEW 885
            :||.|..||        |......|....:|  :.|::..|...||.||:|.:|      ...:|
Worm   732 NAAPHGVLR--------NMELPIPEKVVVSFVAKDLLNMLLVPTPALRPSLDEIRAHPFFRHIDW 788

  Fly   886 LQYGS----------------NDPDVDIILPQQMVVDLSEDTMEQPT 916
            |.|.:                ..|...|.:|:..|.::....:|:|:
Worm   789 LLYDNPTSPSTPATVTRIQSPPTPPSSIDIPEVSVDNVIISNLEEPS 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	40/269 (15%)
		STKc_MSK_N	266..533	CDD:270735	40/267 (15%)
		S_TK_X	532..591	CDD:214529	13/66 (20%)
		S_TKc	632..886	CDD:214567	59/278 (21%)
		PKc_like	632..885	CDD:304357	59/277 (21%)
rskd-1	NP_506082.2	PX_SNX15_like	26..150	CDD:132791	14/91 (15%)
		MIT_SNX15	251..324	CDD:239140	14/78 (18%)
		PKc_like	373..>450	CDD:389743	22/88 (25%)
		PKc_like	<601..783	CDD:389743	55/227 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000