DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and rskn-1

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001122504.1	Gene:	rskn-1 / 172647	WormBaseID:	WBGene00011352	Length:	804	Species:	Caenorhabditis elegans

Alignment Length:	827	Identity:	252/827 - (30%)
Similarity:	397/827 - (48%)	Gaps:	79/827 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 EPNGI---EIDESSSSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDN 231
            ||.||   .|:..|..:.:.|.:....:..:.....::..:....|:......|.:|.  ..|.|
Worm     8 EPFGITPSSIENVSPGIDQCKDHRMDVSMRSDPTDCSSDTTNTFHSSIHIIQPPPNNG--FRLMN 70

  Fly   232 EAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLN 296
            .......|...|:....|  ..|......|::::|||.|::|:||||||:...|:|.:||||||.
Worm    71 WKTDSSSETEIDIGDVRK--CGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLK 133

  Fly   297 KITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENF 361
            |.|:  |.:..:.||.||.:|..|. :||:|.||||||:..||||:|||..||:|||.|.....|
Worm   134 KATL--KVRDRQRTKLERNILAHIS-HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 195

  Fly   362 EESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFC 426
            .|..|:.|:||:.||||.||.|||:|||:|.||||||.:|||.::|||||| ...::|.:.:|||
Worm   196 TEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSK-EAIDSEKKTYSFC 259

  Fly   427 GTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIP 491
            ||:||||||:|..  .||..|.|:||:|||.||:|||..||...|    :::...:|.|.:..:|
Worm   260 GTVEYMAPEVINR--RGHSMAADFWSLGVLMFEMLTGHLPFQGRD----RNDTMTQILKAKLSMP 318

  Fly   492 SSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDD 556
            ...:..|:..:..:.::|.:.|||.......|||.|.||..|::.:|..|....|:||.|:..|.
Worm   319 HFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDS 383

  Fly   557 VQNFSNEFTDQVPED-PECDAPPSRIRLFRGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPCR- 619
            ...|..|||.:.|:| |...|..:...:|||:::|:...:|        |.:.....::::|..
Worm   384 TSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVSNAVME--------ERKLIAKSVRSVPTAK 440

  Fly   620 ----PDDLELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKF-RPSEVDALISCALDTTNHKN 679
                .||.|:..:..|||:...|.....:|...:..||:..:.| ...|||.|    |..::|:.
Worm   441 TNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDIL----LRHSHHQF 501

  Fly   680 IVSYHGTFREKCETWIVMEYLSGPELTASI-----RMDEDSCREIFLQLVMAVRHIHSKHFIHGD 739
            :|.....:.::...:::.|...|.||...:     ...|.....|...|:.||:::||:...|.|
Worm   502 VVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRD 566

  Fly   740 LKPENIMF--ENREDRTVKLIDFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDI 802
            |...||:|  ::.:..:::::|||.|..:.........|.||..:..||:|....   |..:.|:
Worm   567 LTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQG---YDRSCDV 628

  Fly   803 YGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCL 867
            :.||..|:|||.|..|:....:|..      .::.:|:..|..:.....|::.|...:.||...|
Worm   629 WSLGVLLHTMLTGCTPFAMGPNDTP------DQILQRVGDGKISMTHPVWDTISDEAKDLVRKML 687

  Fly   868 QRDPADRPTLSDILDSEWLQYGSNDPDVDIILPQQMVVDLSEDTMEQPTGGMFDDQQQLEFMHDK 932
            ..||..|.|....|..:|:  |..:...|..:..:.|.:|              |.|.::|.
Worm   688 DVDPNRRVTAKQALQHKWI--GQKEALPDRPIQSEQVGEL--------------DMQNVKFQ--- 733

  Fly   933 SAEDEGITLVSEPMDTTVATHESRRNAAAFSSVVAPTTDDEIVHERF 979
                    :..|.....:|:..|.:.....||.:|.....||::..:
Worm   734 --------VALEQTYKAIASAPSVQLRPVGSSALAKRRMKEILYANY 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	127/268 (47%)
		STKc_MSK_N	266..533	CDD:270735	128/266 (48%)
		S_TK_X	532..591	CDD:214529	19/59 (32%)
		S_TKc	632..886	CDD:214567	64/261 (25%)
		PKc_like	632..885	CDD:304357	64/260 (25%)
rskn-1	NP_001122504.1	S_TKc	98..357	CDD:214567	127/268 (47%)
		STKc_RSK_N	102..418	CDD:270734	147/325 (45%)
		STKc_RSK_C	447..744	CDD:270993	76/336 (23%)
		S_TKc	448..706	CDD:214567	66/270 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920