DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JIL-1 and Sgk3

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001362972.1	Gene:	Sgk3 / 171498	RGDID:	620242	Length:	496	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	151/387 - (39%)
Similarity:	211/387 - (54%)	Gaps:	34/387 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 LDLDNEAHQRDLEAVTDLKYYVKLYS-DEAVSL----------NDFKIIRVLGTGAYGRVFLV-R 279
            |.:|:..||.|.....|.:...|.:| ...::|          :||..::|:|.|::|:|.|. |
  Rat   117 LQMDSPRHQSDPSEDEDERSTPKPHSTSRNINLGPTGNPHAKPSDFDFLKVIGKGSFGKVLLAKR 181

  Fly   280 KLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLD 344
            ||.    ||.||:|||.| .:|..||..:|...||.||....::||||.|||:||::.|||.|||
  Rat   182 KLD----GKFYAVKVLQK-KIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLD 241

  Fly   345 FANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFG 409
            |.||||||.||....:|.|.|.|.|.||:..||..||.:.|:|||:|.||||||..||:||:|||
  Rat   242 FVNGGELFFHLQRERSFPEPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSMGHVVLTDFG 306

  Fly   410 LSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQV 474
            |.|...|.:: ...:||||.||:|||:||..|  :|:.||||.:|.:.:|:|.|..||...|...
  Rat   307 LCKEGIAISD-TTTTFCGTPEYLAPEVIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE 368

  Fly   475 QQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELR 539
            ....|..:....:|.:    |..|...:.::||||.:.|||.. .|..||:.||||..::|.:|.
  Rat   369 MYDNILHKPLNLRPGV----SLTAWSILEELLEKNRQNRLGAK-EDFLEIQNHPFFESLSWTDLV 428

  Fly   540 TKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPSRI---------RLFRGYTYVAP 592
            .|:...|:.|.:...||::||...||::......|.:....|         ..|.|::|..|
  Rat   429 QKKIPPPFNPNVAGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	122/269 (45%)
		STKc_MSK_N	266..533	CDD:270735	123/267 (46%)
		S_TK_X	532..591	CDD:214529	16/67 (24%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
Sgk3	NP_001362972.1	PX_CISK	12..120	CDD:132780	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..157		7/35 (20%)
		STKc_SGK3	165..490	CDD:270755	139/337 (41%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000