DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and Rps6ka2

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_038934903.1	Gene:	Rps6ka2 / 117269	RGDID:	620676	Length:	762	Species:	Rattus norvegicus

Alignment Length:	762	Identity:	266/762 - (34%)
Similarity:	378/762 - (49%)	Gaps:	86/762 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EDEPNGIEIDESSSSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDNE 232
            |.||..||..|...||....:.............|:|....||||::
  Rat    14 EVEPMEIETTEEELSLDIEPTPEDTTEEGKGDTTASAETQPASSSSS------------------ 60

  Fly   233 AHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNK 297
            |.:..:....|:..:|| ...|....:.|::::|||.|:||:||||||:|..|||:|||||||.|
  Rat    61 AEEEGIVKEIDISSHVK-EGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKK 124

  Fly   298 ITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFE 362
            .|:  |.:....:|.||.:|..: .:||:|.||||||:..||||:|||..||:|||.|.....|.
  Rat   125 ATL--KVRDRVRSKMERDILAEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT 186

  Fly   363 ESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCG 427
            |..|:.|:||:.|||:.||.|||||||:|.||||||.||||.::|||||| ...:::.||:||||
  Rat   187 EEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSK-EAIDHDKRAYSFCG 250

  Fly   428 TLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPS 492
            |:||||||::..  .||..:.||||.|||.||:|||:.||...|    :.|....|.|.:..:|.
  Rat   251 TIEYMAPEVVNR--RGHTQSADWWSFGVLMFEMLTGSLPFQGKD----RKETMALILKAKLGMPQ 309

  Fly   493 SFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDV 557
            ..||.|:..:..:.::||..|||.......|||.||||..|:|.:|..|..|.|:||.:...:|.
  Rat   310 FLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTIDWNKLYRKEIKPPFKPAVGRPEDT 374

  Fly   558 QNFSNEFTDQVPEDPECDAPPS--RIRLFRGYTYVAPEHLEQMRRDNHCEIQYFNTGLQNIPCRP 620
            .:|..|||.:.|.|.. ..|||  ...||||:::||...:::..:             |::|..|
  Rat   375 FHFDPEFTARTPTDSP-GVPPSANAHHLFRGFSFVASSLVQEPSQ-------------QDVPKAP 425

  Fly   621 ----------------DDLELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALIS 669
                            |..|:......|:|..|...|..:||..:..|||..||..|||.   |.
  Rat   426 IHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSEE---IE 487

  Fly   670 CALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASIR----MDEDSCREIFLQLVMAVRHI 730
            ..|....|.||::....:.:....::|||.:.|.||...|.    ..|....::...:...:.::
  Rat   488 ILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYL 552

  Fly   731 HSKHFIHGDLKPENIMF--ENREDRTVKLIDFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANL 793
            ||:..:|.||||.||::  |:....::::.|||.|............|.||.::..||:|....
  Rat   553 HSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQG- 616

  Fly   794 VTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPA 858
              |..|.|::.||..|||||.|..|:....||..      .|:..|:..|.:......|:|.|.|
  Rat   617 --YDAACDVWSLGILLYTMLAGFTPFANGPDDTP------EEILARIGSGKYALSGGNWDSISDA 673

  Fly   859 FRHLVSWCLQRDPADRPTLSDILDSEWL---QYGSND----PDVDII 898
            .:.:||..|..||..|.|...:|...|:   :|.|.:    .||.::
  Rat   674 AKDVVSKMLHVDPQQRLTAVQVLKHPWIVNREYLSQNQLSRQDVHLV 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	135/268 (50%)
		STKc_MSK_N	266..533	CDD:270735	136/266 (51%)
		S_TK_X	532..591	CDD:214529	22/60 (37%)
		S_TKc	632..886	CDD:214567	76/259 (29%)
		PKc_like	632..885	CDD:304357	76/258 (29%)
Rps6ka2	XP_038934903.1	STKc_RSK_N	92..408	CDD:270734	158/326 (48%)
Rps6ka2	XP_038934903.1	STKc_RSK3_C	440..732	CDD:271080	83/293 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750