DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JIL-1 and akt3b

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_001923454.3	Gene:	akt3b / 100149794	ZFINID:	ZDB-GENE-110309-3	Length:	479	Species:	Danio rerio

Alignment Length:	389	Identity:	145/389 - (37%)
Similarity:	211/389 - (54%)	Gaps:	44/389 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 TPSYAMPTSNSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLV 278
            :|...:...|...:|.....|:|.                   ::|||..:::||.|.:|:|.||
Zfish   120 SPISQIENVNEEEMDTSTSHHKRK-------------------TMNDFDYLKLLGKGTFGKVILV 165

  Fly   279 RKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVL 343
            |:..   :|..||||:|.|..::.|.:.| ||.||..||:. .|:|||.||.|:||:..:|..|:
Zfish   166 REKA---SGTYYAMKILKKEVIIAKDEVA-HTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVM 225

  Fly   344 DFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDF 408
            ::.||||||.||.....|.|.|.|.|.||:|.||:.||...|:|||:||||::||.:|||.::||
Zfish   226 EYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSAKIVYRDLKLENLMLDKDGHIKITDF 290

  Fly   409 GLSK--ILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSD 471
            ||.|  |..|..   ..:||||.||:|||::.....|.  |||||.:||:.:|::.|..||...|
Zfish   291 GLCKEGITDAAT---MKTFCGTPEYLAPEVLEDNDYGR--AVDWWGLGVVMYEMMCGRLPFYNQD 350

  Fly   472 GQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQ 536
                ..::...|..|:...|.:.||:|:..:..:|.|:|.:||||...||.||..|.||..::||
Zfish   351 ----HEKLFELILMEEIKFPRTLSADAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFTALDWQ 411

  Fly   537 ELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQV-----PE---DPECDAPPSRIR-LFRGYTYVA 591
            ::..|:...|:.|.:::|.|.:.|..|||.|.     ||   :...||..|..| .|..::|.|
Zfish   412 DVYDKKLVPPFMPQVSSETDTRYFDEEFTAQTITITPPEKYDEDGMDAADSERRPHFPQFSYSA 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	115/270 (43%)
		STKc_MSK_N	266..533	CDD:270735	116/268 (43%)
		S_TK_X	532..591	CDD:214529	20/67 (30%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
akt3b	XP_001923454.3	PH_PKB	4..109	CDD:269947
		PH	6..105	CDD:278594
		PKc_like	132..479	CDD:304357	143/377 (38%)
		S_TKc	148..405	CDD:214567	115/270 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910