DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JIL-1 and rps6ka3b

DIOPT Version :9

Sequence 1:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_009295647.1	Gene:	rps6ka3b / 100009657	ZFINID:	ZDB-GENE-070209-74	Length:	739	Species:	Danio rerio

Alignment Length:	709	Identity:	253/709 - (35%)
Similarity:	369/709 - (52%)	Gaps:	49/709 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 AASKASSSTTPSYAMPTS--NSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVL 267
            |...|:|.|.|.:.:..|  ....|....|...:::    ::.:.||..|::| ....|::.:||
Zfish    14 AIGSAASETEPHHVLEDSMGEDENLSCQEEVSVKEI----NITHLVKEGSEKA-DPQQFELRKVL 73

  Fly   268 GTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYA 332
            |.|::|:||||:|.|..|||:|||||||.|.|:  |.:....||.||.:|..: .:||:|.||||
Zfish    74 GQGSFGKVFLVKKTTGPDAGQLYAMKVLKKATL--KVRDQVRTKMERDILVEV-NHPFIVKLHYA 135

  Fly   333 FQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILL 397
            ||:..||||:|||..||:|||.|.....|.|..|:.|:||:.|||:.||.|||||||:|.|||||
Zfish   136 FQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILL 200

  Fly   398 DGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLT 462
            |.:|||.|:|||||| .:.::|.:|:|||||:||||||::..  .||..:.||||.|||.:|:||
Zfish   201 DEDGHIKLTDFGLSK-ESIDHENKAYSFCGTVEYMAPEVVNR--RGHTYSADWWSYGVLMYEMLT 262

  Fly   463 GASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEH 527
            |..||...|    :.|....|.|.:..:|...|:.|:..:..:.::||..|||.......|||.|
Zfish   263 GTLPFQGKD----RKETMTMILKAKLGMPQFLSSEAQSLLRSLFKRNPTNRLGAGPDGVEEIKRH 323

  Fly   528 PFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPS--RIRLFRGYTYV 590
            ||:..|:|.:|..:....|:||.....||...|..|||.:.|:|.. ..|||  ..|||||:::|
Zfish   324 PFYVSIDWNKLFRRESHPPFKPATGRPDDTFYFDPEFTAKTPKDSP-GVPPSANANRLFRGFSFV 387

  Fly   591 A--PEHLEQMRRDNHCE--IQYFNTGLQNIPCRPDDLELGTRTSNGAYGTCHFVVDSSTDLVFLA 651
            |  .|...|....|...  :|..:   :|:....|..|:......|||..|...:..||.:.:..
Zfish   388 AITSEEESQSLPSNSMSSIVQQLH---RNVSQFSDAYEVKEDIGIGAYSICKRCIQKSTMMEYAV 449

  Fly   652 KIIPLSKFRPS-EVDALISCALDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASIR----- 710
            |||..:|..|: ||:.|:...    .|.||::....:.:....::|.|.|.|.||...|.
Zfish   450 KIISKAKRDPAEEVEILLRYG----QHPNIITLKDVYDDGRTVYLVTELLKGGELLDKILRQKFF 510

  Fly   711 MDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMF--ENREDRTVKLIDFGSACYNNRFKSWK 773
            .:.::| .:...:...|.::|::..:|.||||.||::  |:....::::.|||.|..........
Zfish   511 SEREAC-AVLHTITKTVAYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLL 574

  Fly   774 DKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRK 838
            ..|.||.::..||:|....   |..|.||:.||..|||||.|..|:....:|..      .|:..
Zfish   575 MTPCYTANFVAPEVLKKQG---YDAACDIWSLGVLLYTMLTGFTPFANGPEDTP------EEILA 630

  Fly   839 RMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDPDVDI 897
            |:..|.|:.....|.|.|...:.|||..|..||..|.|.:.:|...|:.:....|:..:
Zfish   631 RIGSGQFSLTGGFWNSVSCQAKDLVSKMLHVDPHQRLTAAQVLKHPWITHKDKLPNYQL 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	132/268 (49%)
		STKc_MSK_N	266..533	CDD:270735	132/266 (50%)
		S_TK_X	532..591	CDD:214529	22/60 (37%)
		S_TKc	632..886	CDD:214567	75/261 (29%)
		PKc_like	632..885	CDD:304357	75/260 (29%)
rps6ka3b	XP_009295647.1	S_TKc	67..325	CDD:214567	131/267 (49%)
		STKc_RSK_N	71..387	CDD:270734	154/326 (47%)
		PKc_like	403..739	CDD:304357	81/304 (27%)
		Pkinase	421..678	CDD:278497	76/270 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850