DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mocs1 and moc-5

DIOPT Version :9

Sequence 1:	NP_788494.1	Gene:	Mocs1 / 39238	FlyBaseID:	FBgn0263241	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_509612.2	Gene:	moc-5 / 181176	WormBaseID:	WBGene00009885	Length:	600	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	266/566 - (46%)
Similarity:	361/566 - (63%)	Gaps:	59/566 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RGAIRLKATTGYLNLATASVQPLEPEKQVLRKNSPLTDSFGRHHTYLRISLTERCNLRCDYCMPA 90
            |.|:|||            :|.:|..|    ...|..|.|.|.||||||||||:||.||.|||||
Worm    46 REAVRLK------------IQEIEHTK----GQPPFFDMFMREHTYLRISLTEKCNFRCLYCMPA 94

  Fly    91 EGVPLQPKNKLLTTEEILRLARIFVEQGVRKIRLTGGEPTVRRDIVEIVAQMKALPELEQIGITT 155
            |||||:||:|:|:..|:|||.::|...||.|:||||||||:|:|||.||..:.:.|.::::||||
Worm    95 EGVPLKPKDKMLSNSEVLRLVKLFAAHGVDKVRLTGGEPTIRKDIVHIVEGISSTPGIKEVGITT 159

  Fly   156 NGLVLTRLLLPLQRAGLDNLNISLDTLKRDRFEKITRRKGWERVIAGIDLAVQLGYRPKV--NCV 218
            |||||.|.|..|:.|||..:|||:|:|.|::|.|:|||.|:::|...|:||  .||.|||  |.|
Worm   160 NGLVLQRFLPQLRDAGLTKINISIDSLDREKFAKMTRRDGFDKVWKAIELA--RGYYPKVKLNVV 222

  Fly   219 LMRDFNEDEICDFVEFTRNRPVDVRFIEYMPFSGNKWHTERLISYKDTLQIIRQRWPD-FKALPN 282
            :::..||:|:.|||..|::|.:||||||:|||.||::..:..|.|::.|.:|..::.| ...|.:
Worm   223 VLKHQNENEVVDFVNLTKDRNLDVRFIEFMPFGGNEFKNDNFIGYREMLNLIVDKYGDGVIRLSD 287

  Fly   283 GPNDTSKAYAVPGFKGQVGFITSMTEHFCGTCNRLRLTADGNIKVCLFGNKEFSLRDAMRDESVS 347
            .||||:|||.:.||:||.||||||::|||.||||||:|||||:||||.||.|.||||.:|... |
Worm   288 SPNDTTKAYKIDGFQGQFGFITSMSDHFCNTCNRLRITADGNLKVCLHGNSEVSLRDRIRCGD-S 351

  Fly   348 EEQLVDLIGAAVQRKKKQHA------------------------DAAPRLHHHLHPYSYHHAY-H 387
            :|||.::|..||..||.:||                        .:|..:..||...|.:|:: |
Worm   352 DEQLSEVIQKAVNNKKARHAVFRNGRSEEPAKSSNDSYRGLTPVTSASSILVHLPSSSLYHSHLH 416

  Fly   388 TSR------LQLQARNYS------QLTHVDGQGKAQMVDVGAKPSTTRLARAEATVQVGEKLTQL 440
            :||      ::..:..||      .|||||..|.|:.|||..|.::||.|.|..|:.:..::::.
Worm   417 SSRHFFISQIRCFSTTYSVSSITHLLTHVDNNGNAKQVDVSQKDTSTRTAVARGTIILTAEISRQ 481

  Fly   441 IADNQVAKGDVLTVAQIAGIMGAKRTAELIPLCHNISLSSVKVQATLLKTEQSVRLEATVRCSGQ 505
            |::|.:.||||||||:||.|:|||:.|.||||||.|.|..|............:...:|.||||.
Worm   482 ISENTIKKGDVLTVAKIASILGAKQVANLIPLCHPIRLDFVDTVFNHDIENSKLHCISTARCSGN 546

  Fly   506 TGVEMEALTAVSVAALTVYDMCKAVSHDICITNVRLLSKSGGKRDF 551
            ||||||||||.::|.|||||||||:|..:.:||:.|:.|||||..:
Worm   547 TGVEMEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKTTY 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mocs1	NP_788494.1	moaA	59..366	CDD:234672	170/309 (55%)
		Radical_SAM	74..249	CDD:100105	98/176 (56%)
		Mob_synth_C	240..367	CDD:283994	69/127 (54%)
		moaC	399..555	CDD:236483	77/159 (48%)
moc-5	NP_509612.2	moaA	67..391	CDD:274250	171/326 (52%)
		Radical_SAM	78..258	CDD:100105	102/181 (56%)
		Mob_synth_C	244..371	CDD:283994	69/127 (54%)
		MoaC_PE	454..589	CDD:238708	67/134 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167343
Domainoid	1	1.000	181	1.000	Domainoid score	I2068
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4343
Inparanoid	1	1.050	475	1.000	Inparanoid score	I819
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55967
OrthoDB	1	1.010	-	-		D337398at33208
OrthoFinder	1	1.000	-	-		FOG0005129
OrthoInspector	1	1.000	-	-		otm14715
orthoMCL	1	0.900	-	-		OOG6_101306
Panther	1	1.100	-	-	LDO	PTHR22960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4665
SonicParanoid	1	1.000	-	-		X3650
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940