DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7888 and AVT2

DIOPT Version :9

Sequence 1:	NP_648425.1	Gene:	CG7888 / 39232	FlyBaseID:	FBgn0036116	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_010850.1	Gene:	AVT2 / 856645	SGDID:	S000000790	Length:	480	Species:	Saccharomyces cerevisiae

Alignment Length:	494	Identity:	88/494 - (17%)
Similarity:	175/494 - (35%)	Gaps:	125/494 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KGQKNKAVVAKDPDYNPYHH--RDVEHPTTNSETLFHLLKGSLGTGILAMPNAFRNSGYITGSIG 89
            :||.:..::..|.|....:.  |:.:..::......:|....||.||:..|.|.:|:|.:.|.:.
Yeast    39 QGQNSLNIITPDMDDTLVNDVLRENDKKSSMRMAFMNLANSILGAGIITQPFAIKNAGILGGLLS 103

  Fly    90 TIVIGFICTFCIHQLVKAQYELCRRKKMPSMNYPMVAETAMGEGPKCFRVFAPYIGTVVNTFLLI 154
            .:.:|||..:.: :|:.....|..::     .|....|..||:..|...:|...          :
Yeast   104 YVALGFIVDWTL-RLIVINLTLAGKR-----TYQGTVEHVMGKKGKLLILFTNG----------L 152

  Fly   155 YQLGTCCVYVVFVASNI--------------------------------------KAIVDAVADT 181
            :..|.|..|.:.:...|                                      |..::|::..
Yeast   153 FAFGGCIGYCIIIGDTIPHVLRAIFSQNDGNVHFWLRRNVIIVMVTTFISFPLSMKRNIEALSKA 217

  Fly   182 SIDVRLCMIIILL------PLILINWVRNLKYLAPF---STLANAITMVSFGIICYYIFREPVTT 237
            |....:.||||:|      |::..:|..:...|:.|   :|:..:::::||.::|::
Yeast   218 SFLAVISMIIIVLTVVIRGPMLPYDWKGHSLKLSDFFMKATIFRSLSVISFALVCHH-------- 274

  Fly   238 EGKDAFGKPSNFPLFFGTVLFALEAIGVILPLENEMKTPQKFGGSCGVLNVSMVLIVFLYVGMGL 302
                    .::| :||.              :.|  ::..||   ..:.::|:::.|.....||.
Yeast   275 --------NTSF-IFFS--------------MRN--RSVAKF---TRLTHISIIISVICCALMGY 311

  Fly   303 FGYLNYGSAVLGSITLNMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWN-----------D 356
            .|:..:.....|::..:.|..:......:....|.:..|..:..:|..|:..|           |
Yeast   312 SGFAVFKEKTKGNVLNSFPGTDTAINIARLCFGFNMLTTFPMEIFVLRDVVGNLLHECNLIKNYD 376

  Fly   357 YVAKRLGAQRNALFWEYAVRTGLVLITFLLAVAIPNLELFISLFGALCLSALGLAFPALIQICTH 421
            ...:..|.|      ...:.:.||.||..:::...||.....|.||...|.:....|....:.
Yeast   377 EHTQLSGKQ------HVVITSSLVFITMGISLTTCNLGALFELIGATTASTMAYILPPYTNLL-- 433

  Fly   422 WYNTKGFAKVWLVLSNFVLIIVGILGLVIGTYTSLKEIV 460
             ..:|  .|.|.....|.|.|  ..|.:|...:|.:.|:
Yeast   434 -LTSK--KKSWKERLPFYLCI--CFGFMIMIISSTQTII 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7888	NP_648425.1	SLC5-6-like_sbd	51..453	CDD:294310	81/459 (18%)
CG7888	NP_648425.1	SdaC	62..456	CDD:223884	81/451 (18%)
AVT2	NP_010850.1	Aa_trans	65..467	CDD:279788	82/466 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820