DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7888 and AVT4

DIOPT Version :9

Sequence 1:	NP_648425.1	Gene:	CG7888 / 39232	FlyBaseID:	FBgn0036116	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_014298.1	Gene:	AVT4 / 855622	SGDID:	S000005045	Length:	713	Species:	Saccharomyces cerevisiae

Alignment Length:	518	Identity:	132/518 - (25%)
Similarity:	236/518 - (45%)	Gaps:	105/518 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPVMTKN--------GH-SNSAYVADH-PDKLELAEKGQKNKAVVAKDPDYNPYHHRDV---EHP 52
            :|.:|:|        || :..::..|. ||...:..:|:..::.:...||     |..|   ...
Yeast   236 VPFLTRNFLEFLYVFGHFAGESFEDDFIPDSSNMMIRGEDERSALLSRPD-----HMKVLPSAKG 295

  Fly    53 TTNSETLF-HLLKGSLGTGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKK 116
            ||:::.:| .|||..:|||:|.:||||.|.|...........|....:|.:.||:|: ..|
Yeast   296 TTSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFFSVSMLAFFGIYSYWCYYILVQAK-SSC---- 355

  Fly   117 MPSMNYPMVAETAMGEGPKCF-----RVFAPYIGTVVNTFLLIYQLGTCCVYVVFVASNIKAIVD 176
                            |...|     :::.|::..::...|:|.|:|....|::|.|.|::|.:|
Yeast   356 ----------------GVSSFGDIGLKLYGPWMRIIILFSLVITQVGFSGAYMIFTAKNLQAFLD 404

  Fly   177 AVADTSI-DVRLCMI---IILLPLILINWVRNLKYLAPFSTLANAITMVSFGIICYYIFREPVTT 237
            .|....: .:...|:   ||.:||   :::||:..|:..|.|||...|.  |::...||     |
Yeast   405 NVFHVGVLPLSYLMVFQTIIFIPL---SFIRNISKLSLPSLLANFFIMA--GLVIVIIF-----T 459

  Fly   238 EGK---DAFGKPS----------NFPLFFGTVLFALEAIGVILPLENEMKTPQKFGGSCGVLNVS 289
            ..:   |..|.|:          .:.||.||.:||.|.||:|:|:::.|:.|:||     .|.::
Yeast   460 AKRLFFDLMGTPAMGVVYGLNADRWTLFIGTAIFAFEGIGLIIPVQDSMRNPEKF-----PLVLA 519

  Fly   290 MVLI--VFLYVGMGLFGYLNYGSAVLGSITLNMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDI 352
            :|::  ..|::.:...|||.|||.|...|.||:|:..:....::...:.||.::..|..:.||.|
Yeast   520 LVILTATILFISIATLGYLAYGSNVQTVILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKI 584

  Fly   353 TWNDYVAK-------------RLGAQRNA--LFWEYA-----VRTGLVLITFLLA-VAIPNLELF 396
            ..|.:..|             |:..:.|:  |.|:..     :|:.:|:|...:| ....||:.|
Yeast   585 IENKFFPKFTKIYVKHDDLTTRVELRPNSGKLNWKIKWLKNFIRSIIVIIVVSIAYFGSDNLDKF 649

  Fly   397 ISLFGALCLSALGLAFPALIQICTHWY-NTKGFAKVWLV--LSNFVLIIVGILGLVIGTYTSL 456
            :|:.|:|....|...:|:::.:..:.. .|||  :.|..  :.:.:||..||..::..:|.|:
Yeast   650 VSVIGSLACIPLVYIYPSMLHLRGNSLPETKG--EFWRFKPMLDTILIFFGIASMLYTSYQSI 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7888	NP_648425.1	SLC5-6-like_sbd	51..453	CDD:294310	117/450 (26%)
CG7888	NP_648425.1	SdaC	62..456	CDD:223884	115/441 (26%)
AVT4	NP_014298.1	Aa_trans	295..711	CDD:279788	119/454 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I928
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm9188
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
TreeFam	0	0.000	Not matched by this tool.
	8	7.860