DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7888 and AVT3

DIOPT Version :9

Sequence 1:	NP_648425.1	Gene:	CG7888 / 39232	FlyBaseID:	FBgn0036116	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_012776.1	Gene:	AVT3 / 853710	SGDID:	S000001629	Length:	692	Species:	Saccharomyces cerevisiae

Alignment Length:	473	Identity:	111/473 - (23%)
Similarity:	215/473 - (45%)	Gaps:	50/473 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MTKNGHSNSAYVADHPDKLELAEKGQKNKAVVAKDPDYNPYHHRDVEHPTTNSETLFHLLKGSLG 68
            :|..||.....:::..::.|..|:..:.:|:..:........|....|.::..:.:..|||..:|
Yeast   248 LTLYGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTVKAVLLLLKSFVG 312

  Fly    69 TGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKKMPSMNYPMVAETAMGEG 133
            ||:|.:|.||.|.|:...::..:....|...|...|:..:.::                ...|.|
Yeast   313 TGVLFLPKAFHNGGWGFSALCLLSCALISYGCFVSLITTKDKV----------------GVDGYG 361

  Fly   134 PKCFRVFAPYIGTVVNTFLLIYQLGTCCVYVVFVASNIKAIVD---AVADTSIDVR---LCMIII 192
            .....::.|.:...:.:.:.:.|:|....|.||.|:|::...:   .:...||.:.   ...::|
Yeast   362 DMGRILYGPKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYIFAQVLI 426

  Fly   193 LLPLILINWVRNLKYLAPFSTLANAITMVSFGII------CYYIFREPVTTEGKDAFGKPSNFPL 251
            .:||.|   .||:..|:..:.:|:...::  |::      .|||....|.::....|.| :::.|
Yeast   427 FVPLSL---TRNIAKLSGTALIADLFILL--GLVYVYVYSIYYIAVNGVASDTMLMFNK-ADWSL 485

  Fly   252 FFGTVLFALEAIGVILPLENEMKTPQKFGGSCGVLNVSMVLIVFLYVGMGLFGYLNYGSAVLGSI 316
            |.||.:|..|.||:::|::..||.|:.|..|   |:..|.::..:::..||..|..:||.|...:
Yeast   486 FIGTAIFTFEGIGLLIPIQESMKHPKHFRPS---LSAVMCIVAVIFISCGLLCYAAFGSDVKTVV 547

  Fly   317 TLNMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWN-DYVAKRLGAQRNALFW-EYAVRTGL 379
            .||.|:....::.|:.:.|.||.::..|..:.||.|..| .:.:...|.....:.| :...|..:
Yeast   548 LLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPKVKWLKNYFRCAI 612

  Fly   380 VLITFLLA-VAIPNLELFISLFGALCLSALGLAFPALIQICTHWYNT--KGFAKVWLVLSNFVLI 441
            |::|.:|| |...:|:.|:||.|:.....|...:|.|:    |:..:  .|.::..|:|.    :
Yeast   613 VVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLL----HYKASILSGTSRARLLLD----L 669

  Fly   442 IVGILGLVIGTYTSLKEI 459
            ||.:.|:.:..|||.:.|
Yeast   670 IVIVFGVAVMAYTSWQTI 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7888	NP_648425.1	SLC5-6-like_sbd	51..453	CDD:294310	100/418 (24%)
CG7888	NP_648425.1	SdaC	62..456	CDD:223884	101/410 (25%)
AVT3	NP_012776.1	Aa_trans	295..687	CDD:279788	103/424 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I928
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm9188
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
TreeFam	0	0.000	Not matched by this tool.
	8	7.860