DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7888 and SLC38A1

DIOPT Version :9

Sequence 1:	NP_648425.1	Gene:	CG7888 / 39232	FlyBaseID:	FBgn0036116	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001265319.1	Gene:	SLC38A1 / 81539	HGNCID:	13447	Length:	503	Species:	Homo sapiens

Alignment Length:	521	Identity:	107/521 - (20%)
Similarity:	200/521 - (38%)	Gaps:	123/521 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KNGHSNSAYVADHPDKLELAEKGQKNKAVVAKDPDYNPYHHRDVEHPTTNSETLFHLLKGSLGTG 70
            :||..||.:::|...:..|.....:.|    |..:|.|       ..|:...::|:|....:|:|
Human    35 ENGQINSKFISDRESRRSLTNSHLEKK----KCDEYIP-------GTTSLGMSVFNLSNAIMGSG 88

  Fly    71 ILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKKMPSMNYPMVAETAMGEGPK 135
            ||.:..|..|:|.:...:....:..:..:.|:.|:     :| .|:...|.|..:.|...|...|
Human    89 ILGLAFALANTGILLFLVLLTSVTLLSIYSINLLL-----IC-SKETGCMVYEKLGEQVFGTTGK 147

  Fly   136 CFRVFAPYIGTVVNTFLLIYQLGTCCVYVVFVASNIKAIV-------DAVADTSIDVRLCMII-- 191
             |.:|.  ..::.||       |....|:..|.:.:.:.:       :..:...:|.|:.::|
Human   148 -FVIFG--ATSLQNT-------GAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVT 202

  Fly   192 --ILLPLILINWVRNLKYLAPFSTLANAITMVSFGIICYYIFREP-------------------- 234
              |:|||.|:   :||.||...|..:.:..:....::.|..|:.|
Human   203 FGIILPLCLL---KNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTC 264

  Fly   235 ----VTTEGKDAFGKPSNFPLFFGTVLFALEAIGVILPLENEMK--TPQKFGGSCGVLNVSMVLI 293
                ||...|..:..|        |:.||......:||:.:|:|  :.:|..   .|.|:|...:
Human   265 TPKYVTFNSKTVYALP--------TIAFAFVCHPSVLPIYSELKDRSQKKMQ---MVSNISFFAM 318

  Fly   294 VFLYVGMGLFGYLNYGSAVLGSITLN-MPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWNDY 357
            ..:|....:||||.:...|...:... ..:.::|.:.|:            ||..||:.:|
Human   319 FVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVR------------LAVIVAVILT---- 367

  Fly   358 VAKRLGAQRNALFWEYAVRTG------------LVLITFLLAVAIPNLELFISLFGALCLSALGL 410
            |.......|::|| |.|.:|.            |:::..||.:.||:::....:.|....:.|..
Human   368 VPVLFFTVRSSLF-ELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIF 431

  Fly   411 AFPALIQI-CTHWYNTKGFAKVWLV-----------LSNFVLIIVGILGLVIGTYTSLKEIVLTF 463
            ..|:.:.: .|.....||..::||.           ||..::::...|.|   .....||:::..
Human   432 ILPSSLYLKITDQDGDKGTQRIWLFLFLQFPVQPCWLSECIILLPAALSL---NMLKRKELIILC 493

  Fly   464 S 464
            |
Human   494 S 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7888	NP_648425.1	SLC5-6-like_sbd	51..453	CDD:294310	94/463 (20%)
CG7888	NP_648425.1	SdaC	62..456	CDD:223884	92/455 (20%)
SLC38A1	NP_001265319.1	SLC5-6-like_sbd	69..480	CDD:382020	92/457 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750