DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7888 and SLC36A1

DIOPT Version :9

Sequence 1:	NP_648425.1	Gene:	CG7888 / 39232	FlyBaseID:	FBgn0036116	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_011535882.1	Gene:	SLC36A1 / 206358	HGNCID:	18761	Length:	482	Species:	Homo sapiens

Alignment Length:	473	Identity:	163/473 - (34%)
Similarity:	256/473 - (54%)	Gaps:	68/473 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KDPDYNPYHHRDV---EHP---------------------TTNSETLFHLLKGSLGTGILAMPNA 77
            ::.||:.|...||   |.|                     ||..:||.|||||::|||:|.:|.|
Human    13 RNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGNIGTGLLGLPLA 77

  Fly    78 FRNSGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKKMPSMNYPMVAETAMG--EGPKC--FR 138
            .:|:|.:.|.|..::||.:...|:..|||..:..|||.....::|   .:|.|.  |...|  .|
Human    78 VKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDY---GDTVMYGLESSPCSWLR 139

  Fly   139 VFAPYIGTVVNTFLLIYQLGTCCVYVVFVASNIKAIVDAVADT--------------SIDVRLCM 189
            ..|.:...||:.||::.|||.||||.||:|.|.|.:::|...|              ::|.||.|
Human   140 NHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYM 204

  Fly   190 IIILLPLILINWVRNLKYLAPFSTLANAITMVSFGIICYYIFRE-------PVTTEGKDAFGKPS 247
            :..|..|:|:.::|||:.|:.||.|||...:||..:|..:|.:.       |:....|
Human   205 LSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWK------- 262

  Fly   248 NFPLFFGTVLFALEAIGVILPLENEMKTPQKFGGSCGVLNVSMVLIVFLYVGMGLFGYLNYGSAV 312
            .:||||||.:|:.|.||::|||||:||.|:||.   .:|.:.||::..||:.:|..|||.:|:.:
Human   263 TYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFP---LILYLGMVIVTILYISLGCLGYLQFGANI 324

  Fly   313 LGSITLNMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWNDYVAKRLGAQRNALFWEYAVRT 377
            .||||||:| :..|...||.:.:..|:.|:.|..||..:|....:|::  ..:...|..:..|||
Human   325 QGSITLNLP-NCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSR--APEHCELVVDLFVRT 386

  Fly   378 GLVLITFLLAVAIPNLELFISLFGALCLSALGLAFPALIQICTHWYNTKGFAKVWLVLSNFVLII 442
            .||.:|.:||:.||.|:|.|||.|::..|||.|..|.|:::.|  :.::|.:.: .:..:.::.|
Human   387 VLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTT--FYSEGMSPL-TIFKDALISI 448

  Fly   443 VGILGLVIGTYTSLKEIV 460
            :|.:|.|:|||.:|.|::
Human   449 LGFVGFVVGTYEALYELI 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7888	NP_648425.1	SLC5-6-like_sbd	51..453	CDD:294310	153/447 (34%)
CG7888	NP_648425.1	SdaC	62..456	CDD:223884	149/418 (36%)
SLC36A1	XP_011535882.1	SLC5-6-like_sbd	53..459	CDD:294310	152/424 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158563
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm8520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.860