DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7888 and SLC36A2

DIOPT Version :9

Sequence 1:	NP_648425.1	Gene:	CG7888 / 39232	FlyBaseID:	FBgn0036116	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_861441.2	Gene:	SLC36A2 / 153201	HGNCID:	18762	Length:	483	Species:	Homo sapiens

Alignment Length:	467	Identity:	162/467 - (34%)
Similarity:	255/467 - (54%)	Gaps:	43/467 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KLELAEKGQKNKAVVAKDP---DYNPYHHRDVEHP--TTNSETLFHLLKGSLGTGILAMPNAFRN 80
            ||:|....:..|.:..||.   |.:|.....::..  .|..:.|.||:||::|||||.:|.|.:|
Human    17 KLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNMGTGILGLPLAVKN 81

  Fly    81 SGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKKMPSMNYPMVAETAMGEGPKCFRVFAPYIG 145
            :|.:.|.:..:|:|||...|:|.|||.....|:|...|.|:|.......:...|..:.....:.|
Human    82 AGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEANPNAWLQNHAHWG 146

  Fly   146 T-VVNTFLLIYQLGTCCVYVVFVASNIKAIVDAVADT--------------SIDVRLCMIIILLP 195
            . :|:.||:|.|||.||||:||:|.|:|.:|:||..|              ::|.||.|:..|..
Human   147 RHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMDSRLYMLSFLPF 211

  Fly   196 LILINWVRNLKYLAPFSTLANAITMVSFGIICYYIFRE-------PVTTEGKDAFGKPSNFPLFF 253
            |:|:..:|||:.|..||.|||...:||..||..||.:|       |:....|       .:||||
Human   212 LVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVASWK-------TYPLFF 269

  Fly   254 GTVLFALEAIGVILPLENEMKTPQKFGGSCGVLNVSMVLIVFLYVGMGLFGYLNYGSAVLGSITL 318
            ||.:|:.|:|||:|||||:||..:.|.   .:|::.|.::..||:||...|||.:|..:..||:|
Human   270 GTAIFSFESIGVVLPLENKMKNARHFP---AILSLGMSIVTSLYIGMAALGYLRFGDDIKASISL 331

  Fly   319 NMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWNDYVAKRLGAQRNALFWEYAVRTGLVLIT 383
            |:| :..|...||.:....|..|:.|..||..:|. ..:...|: :.|.||..:.::|..:|.:|
Human   332 NLP-NCWLYQSVKLLYIAGILCTYALQFYVPAEII-IPFAISRV-STRWALPLDLSIRLVMVCLT 393

  Fly   384 FLLAVAIPNLELFISLFGALCLSALGLAFPALIQICTHWYNTKGFAKVWLVLSNFVLIIVGILGL 448
            .|||:.||.|:|.|||.|::..:||.|..|.|:::.|  :.::|.:.: .:..:.::.|:|.:|.
Human   394 CLLAILIPRLDLVISLVGSVSGTALALIIPPLLEVTT--FYSEGMSPL-TIFKDALISILGFVGF 455

  Fly   449 VIGTYTSLKEIV 460
            |:|||.:|.|::
Human   456 VVGTYQALDELL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7888	NP_648425.1	SLC5-6-like_sbd	51..453	CDD:294310	150/425 (35%)
CG7888	NP_648425.1	SdaC	62..456	CDD:223884	149/415 (36%)
SLC36A2	NP_861441.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..46		5/19 (26%)
SLC36A2	NP_861441.2	SLC5-6-like_sbd	52..463	CDD:320982	152/426 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158609
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm8520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.860