DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7888 and SLC38A10

DIOPT Version :9

Sequence 1:	NP_648425.1	Gene:	CG7888 / 39232	FlyBaseID:	FBgn0036116	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_011522590.1	Gene:	SLC38A10 / 124565	HGNCID:	28237	Length:	1134	Species:	Homo sapiens

Alignment Length:	450	Identity:	103/450 - (22%)
Similarity:	179/450 - (39%)	Gaps:	101/450 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TNSETLFHLLKGSLGTGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQ----LVKAQYELCRR 114
            :|...:.:::...:|..:|.||..|:..|.:   :|.:::.| |::..||    |||:. .|.:|
Human     7 SNWGLITNIVNSIVGVSVLTMPFCFKQCGIV---LGALLLVF-CSWMTHQSCMFLVKSA-SLSKR 66

  Fly   115 KKMPSMNYPMVAETAMGE--GPKCFRVFAPYIGTVVNTFLLIYQLGTCCVYVVFV---ASNIKAI 174
            :          ....:||  .|:.|..:......:|.|.::...||||..:.|.:   .||..|.
Human    67 R----------TYAGLGEAPSPQAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFAR 121

  Fly   175 VDA--VADT-----SIDVRLCMIIILLPLILINWVRNLKYLAPFSTLANAITMVSFGIICYYIFR 232
            :..  |..|     ...|.||   |:|||.|   .||:        :|:..:..:..::.|.:|.
Human   122 LFGFQVGGTFRMFLLFAVSLC---IVLPLSL---QRNM--------MASIQSFSAMALLFYTVFM 172

  Fly   233 EPVTTEGKDAFGKPSNFPLFFGTVL---------------------FALEAIGVILPLENEMKTP 276
            ..:....       ....||.|..|                     ||.::  .:||..:.:..|
Human   173 FVIVLSS-------LKHGLFSGQWLRRVSYVRWEGVFRCIPIFGMSFACQS--QVLPTYDSLDEP 228

  Fly   277 QKFGGSCGVLNVSMVLIVFLYVGMGLFGYLNYGSAVLGSITLNMPEHEVLSMCVKGML-----AF 336
            .....| .:...|:.::...||.:|.|||:::..|..|::.::.|.:.|..|...|.:     .|
Human   229 SVKTMS-SIFASSLNVVTTFYVMVGFFGYVSFTEATAGNVLMHFPSNLVTEMLRVGFMMSVAVGF 292

  Fly   337 AIYITHGLACYVAIDITWNDYVAK----RLGAQRNALFWEYAVRTGLVLITFLLAVAIPNLELFI 397
            .:.|   |.|..|:.....:...|    ..|.....|.:: |:...:|..|.:..:.|||:|..:
Human   293 PMMI---LPCRQALSTLLCEQQQKDGTFAAGGYMPPLRFK-ALTLSVVFGTMVGGILIPNVETIL 353

  Fly   398 SLFGALCLSALGLAFPALIQICTHWYNTKGFAKVWL-VLSNFVLIIVGILGLVIGTYTSL 456
            .|.||...|.:....||||           :.|:.. .||:.|::.||:..||:.|.|:|
Human   354 GLTGATMGSLICFICPALI-----------YKKIHKNALSSQVVLWVGLGVLVVSTVTTL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7888	NP_648425.1	SLC5-6-like_sbd	51..453	CDD:294310	100/445 (22%)
CG7888	NP_648425.1	SdaC	62..456	CDD:223884	101/440 (23%)
SLC38A10	XP_011522590.1	SLC5-6-like_sbd	6..388	CDD:294310	96/434 (22%)
		SdaC	14..404	CDD:223884	101/442 (23%)
		BASP1	488..690	CDD:283191
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810