DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7888 and SLC36A4

DIOPT Version :9

Sequence 1:	NP_648425.1	Gene:	CG7888 / 39232	FlyBaseID:	FBgn0036116	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_689526.2	Gene:	SLC36A4 / 120103	HGNCID:	19660	Length:	504	Species:	Homo sapiens

Alignment Length:	436	Identity:	153/436 - (35%)
Similarity:	234/436 - (53%)	Gaps:	54/436 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ETLFHLLKGSLGTGILAMPNAFRNSGYITGSIGTIVIGFICTFCIHQLVKAQYELCRRKKMPSMN 121
            :||.|||||::|||:|.:|.|.:|:|.:.|.|..:.||.|...|:|.||:..:.||.|.|..::.
Human    63 QTLMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCLRFKKSTLG 127

  Fly   122 YPMVAETAMGEGP-KCFRVFAPYIGTVVNTFLLIYQLGTCCVYVVFVASNIKAIVDAVADT---- 181
            |......||...| .|.:..|.:..:||:.||:|.|||.|.||:||:|.|:|.:.:...::
Human   128 YSDTVSFAMEVSPWSCLQKQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLESKVFI 192

  Fly   182 -------------SIDVRLCMIIILLPLILINWVRNLKYLAPFSTLANAITMVSFGIICYYIFRE 233
                         |:|:|:.|:..|..:||:.::|.||.|...|.|||....||..||..|:.|.
Human   193 SNSTNSSNPCERRSVDLRIYMLCFLPFIILLVFIRELKNLFVLSFLANVSMAVSLVIIYQYVVRN 257

  Fly   234 -------PVTTEGKDAFGKPSNFPLFFGTVLFALEAIGVILPLENEMKTPQKFGGSCGVLNVSMV 291
                   |:....|       .:||||||.:||.|.|||:|||||:||..::|..:   ||:.|.
Human   258 MPDPHNLPIVAGWK-------KYPLFFGTAVFAFEGIGVVLPLENQMKESKRFPQA---LNIGMG 312

  Fly   292 LIVFLYVGMGLFGYLNYGSAVLGSITLNMPEHEVLSMCVKGMLAFAIYITHGLACYVAIDITWND 356
            ::..|||.:...||:.:...:.||||||:|:...|...||.:.:|.|::|:.:..||..:|....
Human   313 IVTTLYVTLATLGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPG 377

  Fly   357 YVAKRLGAQRNALF---W----EYAVRTGLVLITFLLAVAIPNLELFISLFGALCLSALGLAFPA 414
            ..:|         |   |    |:.:|:.||.||...|:.||.|::.||..||:..|.|.|..|.
Human   378 ITSK---------FHTKWKQICEFGIRSFLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPP 433

  Fly   415 LIQICTHWYNTKGFAKVWLVLSNFVLIIVGILGLVIGTYTSLKEIV 460
            |::|.|.   :|....:|:||.|..:...|::|.::|||.:::||:
Human   434 LVEILTF---SKEHYNIWMVLKNISIAFTGVVGFLLGTYITVEEII 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7888	NP_648425.1	SLC5-6-like_sbd	51..453	CDD:294310	149/427 (35%)
CG7888	NP_648425.1	SdaC	62..456	CDD:223884	148/425 (35%)
SLC36A4	NP_689526.2	SLC5-6-like_sbd	58..476	CDD:294310	152/434 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm8520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.860