DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43693 and AVT4

DIOPT Version :9

Sequence 1:	NP_001261694.1	Gene:	CG43693 / 39231	FlyBaseID:	FBgn0263776	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_014298.1	Gene:	AVT4 / 855622	SGDID:	S000005045	Length:	713	Species:	Saccharomyces cerevisiae

Alignment Length:	620	Identity:	157/620 - (25%)
Similarity:	262/620 - (42%)	Gaps:	128/620 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PENLNAPAGKPPLPPRREQLTEKGQSLSLSSFGGSAGNISGSGRKQHLSGAALARHKL------- 61
            |:.|..|.....:.|:.|..|:      |||..|.  |:.|..|::.:.......|:|
Yeast   157 PKRLRRPRSMENVTPKIEHHTK------LSSASGL--NVPGGFRREFIVNKKRQEHQLNDSASSD 213

  Fly    62 -----KMSLKRGGPPPVATSGSGVMTTSLDQQKIPTVTAGYGENEKPKGGKGGQS---KFIRSDM 118
                 ..|:.:..|           :::.|..|:|.:|..:.|.....|...|:|   .|| .|.
Yeast   214 FTSHESDSINQSSP-----------SSNQDIDKVPFLTRNFLEFLYVFGHFAGESFEDDFI-PDS 266

  Fly   119 ADVPVQQAAGSTLPLVISRKKGDDSEDGNYNPFEHRKV----EHPTSDLETFVHLLKGSLGSGIL 179
            :::.:               :|:|......:..:|.||    :..||..:.|:.|||..:|:|:|
Yeast   267 SNMMI---------------RGEDERSALLSRPDHMKVLPSAKGTTSTKKVFLILLKSFIGTGVL 316

  Fly   180 AMPMAFSHAGLWFGLVATFAVGTLCTYCVHILVKCAHILCRRRKIPMMGFADVAEQAFLDGPPAL 244
            .:|.||.:.||:|.:......|....:|.:|||:.      :....:..|.|:..:.:  ||
Yeast   317 FLPNAFHNGGLFFSVSMLAFFGIYSYWCYYILVQA------KSSCGVSSFGDIGLKLY--GP--- 370

  Fly   245 NRWSRFIRFMVNTFLVIDLLGCCCIYLVFVATN----VEQVVRVYMETELSIRVWIMIVTAPLIF 305
              |.|.|   :...|||..:|....|::|.|.|    ::.|..|.:.....:.|:..|:..||.|
Yeast   371 --WMRII---ILFSLVITQVGFSGAYMIFTAKNLQAFLDNVFHVGVLPLSYLMVFQTIIFIPLSF 430

  Fly   306 MCLVRNLKFLTPFSMIANILMFVGIVITFIY----MFSDI---PAPVERPGIV---SVTEWPLFF 360
               :||:..|:..|::||..:..|:||..|:    :|.|:   ||    .|:|   :...|.||.
Yeast   431 ---IRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLFFDLMGTPA----MGVVYGLNADRWTLFI 488

  Fly   361 GTVIFALEGIGVVMSLENDMKNPSHFIGCPSVLNFGMGLVIALYTLVGFFGFLKYGPETQASITL 425
            ||.|||.||||:::.:::.|:||..|   |.||...:.....|:..:...|:|.||...|..|.|
Yeast   489 GTAIFAFEGIGLIIPVQDSMRNPEKF---PLVLALVILTATILFISIATLGYLAYGSNVQTVILL 550

  Fly   426 NLPLEDKLAQSVKLMIAIAIFFTFTLQFYVPVTILWKGLEHK--------------------IRP 470
            |||..:.....::|..:|||..:..||.:..:.|    :|:|                    :||
Yeast   551 NLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKI----IENKFFPKFTKIYVKHDDLTTRVELRP 611

  Fly   471 EKQNIS------EYGLRVFLVLLCGGIA-VALPNLGPFISLIGAVCLSTLGMIVPATIELAVYHE 528
            ....::      :..:|..:|::...|| ....||..|:|:||::....|..|.|:.:.|.....
Yeast   612 NSGKLNWKIKWLKNFIRSIIVIIVVSIAYFGSDNLDKFVSVIGSLACIPLVYIYPSMLHLRGNSL 676

  Fly   529 DPGYGRFNWRL--WKNSGLILFGVVGFVAGTYVSI 561
            ....|.| ||.  ..::.||.||:...:..:|.||
Yeast   677 PETKGEF-WRFKPMLDTILIFFGIASMLYTSYQSI 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43693	NP_001261694.1	SdaC	153..561	CDD:223884	125/454 (28%)
CG43693	NP_001261694.1	SLC5-6-like_sbd	158..562	CDD:294310	124/447 (28%)
AVT4	NP_014298.1	Aa_trans	295..711	CDD:279788	124/447 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I928
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm9188
orthoMCL	1	0.900	-	-		OOG6_100466
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R126
SonicParanoid	1	1.000	-	-		X121
TreeFam	0	0.000	Not matched by this tool.
	10	9.790