DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43693 and AVT3

DIOPT Version :9

Sequence 1:	NP_001261694.1	Gene:	CG43693 / 39231	FlyBaseID:	FBgn0263776	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_012776.1	Gene:	AVT3 / 853710	SGDID:	S000001629	Length:	692	Species:	Saccharomyces cerevisiae

Alignment Length:	594	Identity:	141/594 - (23%)
Similarity:	240/594 - (40%)	Gaps:	115/594 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PPLPPRREQLTEKGQSLSLSSFGGSAGNISGSGRKQHLSGAALA--RHKLKMSLKRGGPPPVATS 76
            |..|.:.:..::...|.|:.|   .|.:.|...|....|.|::|  .|....|...|.|......
Yeast   141 PSSPSQYQYPSQPALSTSIPS---QAPSFSNRKRSMSFSAASIASSSHLNNNSEANGNPLAAIGL 202

  Fly    77 GSGVMTTSLDQQKIPTVTAGYGENEKPKGGKGGQSKFI----RSDMADVPVQ------------- 124
            ....||                 :|:.:...|.:..||    |....|.|:.
Yeast   203 APAPMT-----------------HEEIRAPGGFRRSFIIQKRRKHNVDAPIPNFFTRNFIEFLTL 250

  Fly   125 --QAAGSTLPLVISRKKGDDSEDGNYNP--------------FEHRKVEHPTSDLETFVHLLKGS 173
              ..||..|     .::.::.|:....|              .||.:..|.:|.::..:.|||..
Yeast   251 YGHFAGEDL-----SEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTVKAVLLLLKSF 310

  Fly   174 LGSGILAMPMAFSHAGLWFGLVATFAVGTLCTY-CVHILVKC-AHILCRRRKIPMMGFADVAEQA 236
            :|:|:|.:|.|| |.|.|       ....||.. |..|...| ..::..:.|:.:.|:.|:..
Yeast   311 VGTGVLFLPKAF-HNGGW-------GFSALCLLSCALISYGCFVSLITTKDKVGVDGYGDMGR-- 365

  Fly   237 FLDGPPALNRWSRFIRFMVNTFLVIDLLGCCCIYLVFVATNVEQVVRVYMET-------ELSIRV 294
            .|.||.        ::|.:.:.:.:..:|....|.||.|||::    |:.|.       .:|:..
Yeast   366 ILYGPK--------MKFAILSSIALSQIGFSAAYTVFTATNLQ----VFSENFFHLKPGSISLAT 418

  Fly   295 WIMIVTAPLIFMCLVRNLKFLTPFSMIANILMFVGIVITFIYMFSDIPAPVERPGIVSVT----- 354
            :|.......:.:.|.||:..|:..::||::.:.:|:|..::|....|..    .|:.|.|
Yeast   419 YIFAQVLIFVPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAV----NGVASDTMLMFN 479

  Fly   355 --EWPLFFGTVIFALEGIGVVMSLENDMKNPSHFIGCPSVLNFGMGLVIALYTLVGFFGFLKYGP 417
              :|.||.||.||..||||:::.::..||:|.||  .|| |:..|.:|..::...|...:..:|.
Yeast   480 KADWSLFIGTAIFTFEGIGLLIPIQESMKHPKHF--RPS-LSAVMCIVAVIFISCGLLCYAAFGS 541

  Fly   418 ETQASITLNLPLEDKLAQSVKLMIAIAIFFTFTLQFYVPVTIL--W---KGLEHKIRPEKQNISE 477
            :.:..:.||.|.:.....:|:|:.|:||..:..||.:..:.||  |   .....|..|:.:.:..
Yeast   542 DVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPKVKWLKN 606

  Fly   478 YGLRVFLVLLCGGIA-VALPNLGPFISLIGAVCLSTLGMIVPATIELAVYHEDPGYGRFNWRLWK 541
            | .|..:|:|...:| |...:|..|:||:|:.....|..|.|..:.   |......|....||..
Yeast   607 Y-FRCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLH---YKASILSGTSRARLLL 667

  Fly   542 NSGLILFGV 550
            :..:|:|||
Yeast   668 DLIVIVFGV 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43693	NP_001261694.1	SdaC	153..561	CDD:223884	111/420 (26%)
CG43693	NP_001261694.1	SLC5-6-like_sbd	158..562	CDD:294310	110/415 (27%)
AVT3	NP_012776.1	Aa_trans	295..687	CDD:279788	110/415 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I928
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm9188
orthoMCL	1	0.900	-	-		OOG6_100466
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R126
SonicParanoid	1	1.000	-	-		X121
TreeFam	0	0.000	Not matched by this tool.
	10	9.790