DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43693 and Slc36a4

DIOPT Version :9

Sequence 1:	NP_001261694.1	Gene:	CG43693 / 39231	FlyBaseID:	FBgn0263776	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001101597.1	Gene:	Slc36a4 / 315439	RGDID:	1311528	Length:	500	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	166/477 - (34%)
Similarity:	263/477 - (55%)	Gaps:	40/477 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 ADVPVQQAAGSTLPLVISRK---------KGDDSEDGNYNPFE-HRKV--EHPTSDLETFVHLLK 171
            |..|.:.|....|.:.:.|.         ..|:.::....|.: |.::  :|..|.::|.:||||
  Rat     3 APAPAEAAGCEELDMDVMRPLINEQNFDGSSDEEQEQTLLPMQKHYQLDGQHGISFVQTLMHLLK 67

  Fly   172 GSLGSGILAMPMAFSHAGLWFGLVATFAVGTLCTYCVHILVKCAHILCRRRKIPMMGFADVAEQA 236
            |::|:|:|.:|:|..:||:..|.::...:|.:..:|:||||:|:|.||:|.|...:|::|....|
  Rat    68 GNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKSTLGYSDTVSFA 132

  Fly   237 FLDGP-PALNRWSRFIRFMVNTFLVIDLLGCCCIYLVFVATNVEQVVRVYMET------------ 288
            ....| ..|.|.:.:.|.:|:.||||..||.|.:|:||:|.||:||....:||
  Rat   133 MEASPWSCLQRQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGLLETTVVVSNSSDLSQ 197

  Fly   289 -----ELSIRVWIMIVTAPLIFMCLVRNLKFLTPFSMIANILMFVGIVITFIYMFSDIPAPVERP 348
                 .:.:||:::.....||.:..:|.||.|...|.:|||.|...:||.:.|:...:|.|...|
  Rat   198 VCERRSVDLRVYMLCFLPLLILLVFIRELKSLFVLSFLANISMAASLVIIYQYVVRSMPDPHNLP 262

  Fly   349 GIVSVTEWPLFFGTVIFALEGIGVVMSLENDMKNPSHFIGCPSVLNFGMGLVIALYTLVGFFGFL 413
            .:....::||||||.:||.||||||:.|||.|:....|   |..||.||.:|..||..:...|::
  Rat   263 IVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRESKRF---PQALNIGMAIVTVLYISLATLGYM 324

  Fly   414 KYGPETQASITLNLPLEDKLAQSVKLMIAIAIFFTFTLQFYVPVTILWKGLEHKIRPEKQNISEY 478
            .:..|.:.|||||||.:..|.||||::.:..||.|:::|||||..|:...:..::..:.:.|.::
  Rat   325 CFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPAVTARLHAKWKCICDF 389

  Fly   479 GLRVFLV-LLCGGIAVALPNLGPFISLIGAVCLSTLGMIVPATIELAVYHEDPGYGRFN-WRLWK 541
            |:|..|| :.|.| ||.:|.|...||.:|||..|||.:|:|..:|:..:.:|    .:| |.:.|
  Rat   390 GIRSLLVSITCAG-AVLIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKD----HYNVWMVLK 449

  Fly   542 NSGLILFGVVGFVAGTYVSIIE 563
            |..:...|.|||:.||||::.|
  Rat   450 NISIAFTGFVGFLLGTYVTVEE 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43693	NP_001261694.1	SdaC	153..561	CDD:223884	158/429 (37%)
CG43693	NP_001261694.1	SLC5-6-like_sbd	158..562	CDD:294310	157/423 (37%)
Slc36a4	NP_001101597.1	SLC5-6-like_sbd	54..469	CDD:294310	157/422 (37%)
Slc36a4	NP_001101597.1	PotE	<223..477	CDD:223605	101/257 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1234
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2430
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm8993
orthoMCL	1	0.900	-	-		OOG6_100466
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880