DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43693 and Slc38a1

DIOPT Version :9

Sequence 1:	NP_001261694.1	Gene:	CG43693 / 39231	FlyBaseID:	FBgn0263776	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001159928.1	Gene:	Slc38a1 / 105727	MGIID:	2145895	Length:	485	Species:	Mus musculus

Alignment Length:	532	Identity:	113/532 - (21%)
Similarity:	222/532 - (41%)	Gaps:	95/532 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 SGVMTTSLDQQKIPTVTAGYGENEKPKGGKGGQ--SKFIRSDMADVPVQQAAGSTLPLVISRKKG 140
            ||:..|.|....:|.......::......:.||  |||| ||      :::..|.....:.::|.
Mouse     6 SGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFI-SD------RESRRSLTNSHLEKRKC 63

  Fly   141 DDSEDGNYNPFEHRKVEHPTSDLETFV-HLLKGSLGSGILAMPMAFSHAGLWFGLVATFAVGTLC 204
            |:...|             |:.|...| :|....:|||||.:..|.::.|:...|:...:|..|.
Mouse    64 DEYIPG-------------TTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLILLTSVTLLS 115

  Fly   205 TYCVHILVKCAHILCRRRKIPMMGFADVAEQAFLDGPPALNRWSRFIRF----MVNTFLVIDLLG 265
            .|.:::|:.|:      ::...|.:..:.||.|       ....:.:.|    :.||       |
Mouse   116 IYSINLLLICS------KETGCMVYEKLGEQVF-------GTTGKLVIFGATSLQNT-------G 160

  Fly   266 CCCIYLVFVATNVEQVVRVYMETELSIRVW-------IMIVTAPLIF-MCLVRNLKFL---TPFS 319
            ....||..|...:...::..|..|.:...|       :::||..:|. :||::||.:|   :.||
Mouse   161 AMLSYLFIVKNELPSAIKSLMGEEDAFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFS 225

  Fly   320 MIANILMFVGIVITFIYMFSDIPA-PVERPGIVS--VTE-----WPLFFGTVIFALEGIGV---- 372
            :  :.:||..||:  ||.....|. .||:...||  ||:     :..|....::||..|..
Mouse   226 L--SCMMFFLIVV--IYKKFQTPCMSVEQNSTVSANVTDACTPKYVTFNSKTVYALPTIAFAFVC 286

  Fly   373 ---VMSLENDMKNPSHFIGCPSVLNFGMGLVIALYTLVGFFGFLKYGPETQASITLNL-PLEDKL 433
               |:.:.:::|:.|. .....|.|.....:..:|.|...||:|.:..:.|:.:.... ...|.|
Mouse   287 HPSVLPIYSELKDRSQ-KKMQMVSNISFFAMFVMYFLTAIFGYLTFYEKVQSDLLHKYQSTGDIL 350

  Fly   434 AQSVKLMIAIAIFFTFTLQFYVPVTILWKGLEHKIRPEKQNISEYGL-RVFLVLLCGGIAVALPN 497
            ..:|:|.:.:|:..|..:.|:...:.|::    ..:..|.::..:.| .:.|:::...:.:.:|:
Mouse   351 ILTVRLAVIVAVILTVPVLFFTVRSSLFE----LAKKTKFHLCRHVLVTIILLIIINLLVIFIPS 411

  Fly   498 LGPFISLIGAVCLSTLGMIVPATIELAVYHEDPGYGRFNWRLWKNSGL---ILFGVVGFVAGTYV 559
            :.....::|....:.|..|:|:::.|.:.::|...|  ..|:|....|   :||.::.      :
Mouse   412 MKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKG--TQRIWAALFLGLGVLFSLIS------I 468

  Fly   560 SIIEFHAEFSSG 571
            .::.:....|||
Mouse   469 PLVIYDWACSSG 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43693	NP_001261694.1	SdaC	153..561	CDD:223884	93/443 (21%)
CG43693	NP_001261694.1	SLC5-6-like_sbd	158..562	CDD:294310	93/439 (21%)
Slc38a1	NP_001159928.1	SLC5-6-like_sbd	69..472	CDD:382020	94/452 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820