DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43693 and slc36a4

DIOPT Version :9

Sequence 1:	NP_001261694.1	Gene:	CG43693 / 39231	FlyBaseID:	FBgn0263776	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_002940192.3	Gene:	slc36a4 / 100493349	XenbaseID:	XB-GENE-994062	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	493	Identity:	169/493 - (34%)
Similarity:	274/493 - (55%)	Gaps:	48/493 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ENEKPKGGKGGQSKFIRSDMADVPVQQAAGST-----LPLVISRKKGDDSED-GNYNPFEHRKVE 157
            :||....||..:.|:.:..:     |.|...|     .||:   :..|||:. |:.:.:..|:..
Frog    23 KNEDSFDGKYAEKKYSQRHL-----QHAESRTDKEVMKPLI---ENEDDSDGFGDEHQYLQRRQH 79

  Fly   158 HPTSD----LETFVHLLKGSLGSGILAMPMAFSHAGLWFGLVATFAVGTLCTYCVHILVKCAHIL 218
            ..:.|    .:|.:|||||::|:|:|.:|:|..:|||..|.::....|.:..:|::|||:|:|.|
Frog    80 SDSKDGLTFFQTLIHLLKGNIGTGLLGLPLAIKNAGLLLGPISLLFFGIISIHCMNILVRCSHFL 144

  Fly   219 CRRRKIPMMGFADVAEQAFLDGPPA-LNRWSRFIRFMVNTFLVIDLLGCCCIYLVFVATNVEQVV 282
            |:|.|...:|:::....|...||.. |.|.:.|.|.||:.|||:..||.|.:|.||:|.|::||:
Frog   145 CQRYKKANLGYSETVGLALEVGPSGFLQRRASFGRSMVDWFLVVTQLGFCSVYFVFLAENIKQVL 209

  Fly   283 RVYMETE-----------LSIRVWI---MIVTAPLIFMCLVRNLKFLTPFSMIANILMFVGIVIT 333
            .|::.|:           |.:|:::   :.:..||:|   :|:||.|:..|.:||:.|.:.::|.
Frog   210 EVFLATKLQQPGIGGIWTLDLRIYMFSFLPLIIPLVF---IRDLKNLSLLSFLANLSMAISLIIV 271

  Fly   334 FIYMFSDIPAPVERPGIVSVTEWPLFFGTVIFALEGIGVVMSLENDMKNPSHFIGCPSVLNFGMG 398
            :.|:..::..|...|...|...:||||||.|||.||||||:.|||.|::...|   ...||.||.
Frog   272 YQYVIRNLSDPRALPLGTSWKTYPLFFGTAIFAFEGIGVVLPLENRMRDKKDF---SKALNIGMA 333

  Fly   399 LVIALYTLVGFFGFLKYGPETQASITLNLPLEDKLAQSVKLMIAIAIFFTFTLQFYVPVTILWKG 463
            :|.|||..:...|:..:|.:.:.|||||||.:..|.|.||::.:..|:.|:.:|:|||..|:...
Frog   334 IVTALYISLATLGYFCFGDQIKGSITLNLPQDSWLYQVVKILYSFGIYVTYAIQYYVPAEIILPA 398

  Fly   464 LEHKIRPEKQNISEYGLRVFLVLLCGGIAVALPNLGPFISLIGAVCLSTLGMIVPATIELAVY-- 526
            :..:::..::.:.|:.:|.|||.|....||.:|.|...||.:|||..|||.:|:|..:|:..:
Frog   399 VTSRVQKTRKLLCEFTMRFFLVCLTCAFAVLIPRLDLVISFVGAVSSSTLALILPPLVEIITFQK 463

  Fly   527 -HEDPGYGRFNWRLWKNSGLILFGVVGFVAGTYVSIIE 563
             |..|      |.:.|:..:...|.|||:|||||:|.|
Frog   464 EHLSP------WVIAKDIAIAAIGFVGFLAGTYVTIEE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43693	NP_001261694.1	SdaC	153..561	CDD:223884	153/429 (36%)
CG43693	NP_001261694.1	SLC5-6-like_sbd	158..562	CDD:294310	152/425 (36%)
slc36a4	XP_002940192.3	SLC5-6-like_sbd	84..493	CDD:382020	152/420 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	332	1.000	Domainoid score	I1149
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2364
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm9415
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R126
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110