DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klu and ZBTB5

DIOPT Version :9

Sequence 1:	NP_001261690.1	Gene:	klu / 39228	FlyBaseID:	FBgn0013469	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_055687.1	Gene:	ZBTB5 / 9925	HGNCID:	23836	Length:	677	Species:	Homo sapiens

Alignment Length:	696	Identity:	125/696 - (17%)
Similarity:	223/696 - (32%)	Gaps:	201/696 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 HHLPLPHPPPAPPPQLLNFN--HHQQQYLPHMYPAAAAAAQSHSHYGGLQYPHPHALQHQHHPHQ 93
            |:|.....|.:||.:.:...  ..|:.::......:..::..:|...|.:.|.|.:...:.:..|
Human   117 HYLTTRTLPMSPPSERVQEQSARMQRSFMLQQLGLSIVSSALNSSQNGEEQPAPMSSSMRSNLDQ 181

  Fly    94 HQHHLPLAL-SLHQQAAAAAAVAAAVATNHSNNNNQASVANNNIVVPWKQRKRKRLSAVLDKLHH 157
               ..|..: .||::..:|                             ::|.|:||...:|:...
Human   182 ---RTPFPMRRLHKRKQSA-----------------------------EERARQRLRPSIDESAI 214

  Fly   158 NNNNNNNNNNETHSNGMACKAEPMEMKGDLAEDAEQDEDHDGSVPDEEDDSVDQDGDAGKYIKSE 222
            ::....|..:..||.......:.:::        ..:...||...::||.::..|...|
Human   215 SDVTPENGPSGVHSREEFFSPDSLKI--------VDNPKADGMTDNQEDSAIMFDQSFG------ 265

  Fly   223 QPVSEDEENEQEMDQDIEDISGEDLELSHSDDNDQDDSPRISMSPLQLQAAQSNLPQDQNQPMNK 287
                                :.||.::....||...:..::||:.   :|.|.....||.....|
Human   266 --------------------TQEDAQVPSQSDNSAGNMAQLSMAS---RATQVETSFDQEAAPEK 307

  Fly   288 -----ENP---------LHVDIKTE---IPSPYDRYFPIPSPLFGYYLHTKYLNE--------VF 327
                 |||         :.|.:|:|   .|.|.|....:.|...|        :|        |.
Human   308 SSFQCENPEVGLGEKEHMRVVVKSEPLSSPEPQDEVSDVTSQAEG--------SESVEVEGVVVS 364

  Fly   328 RRRHDLYPSPLQHTPSSIASET---------ETSPNAQERK--SSSNHVLPHALLANNSPPPSLP 381
            ..:.||.|.....:.|...|.|         |.:.|.:.:.  |.||.:       |.|...:..
Human   365 AEKIDLSPESSDRSFSDPQSSTDRVGDIHILEVTNNLEHKSTFSISNFL-------NKSRGNNFT 422

  Fly   382 SPPRSESSVTNNVATTTTSSTTKKRSSPK------PKGKKGE--KKPMPPPQE----RPLDLCMR 434
            :...::.::.|..:.....|......||:      |....|.  :.|...|.:    ||:...|.
Human   423 ANQNNDDNIPNTTSDCRLESEAPYLLSPEAGPAGGPSSAPGSHVENPFSEPADSHFVRPMQEVMG 487

  Fly   435 NEVEPKKYKKSGSKSSLESRSAGMMPPPPALSAASSLESMSALSPASSSHSGHMPITSAATPNHQ 499
            .........:.|.:..::...:|       |...||...:...||...:
Human   488 LPCVQTSGYQGGEQFGMDFSRSG-------LGLHSSFSRVMIGSPRGGA---------------- 529

  Fly   500 PPPNSPYANAMNAAHAAAAAAAAAMIKMEMPLHPLHHQQMHHSQVPTTTVGVPVIKGDVASPTTK 564
              .|.||..               .|..:||:    ...:..||:|..:....::.....|
Human   530 --SNFPYYR---------------RIAPKMPV----VTSVRSSQIPENSTSSQLMMNGATS---- 569

  Fly   565 ETVAWRYNLDVSPVVEEMPPGSDVAYVCPTCGQMFSLHDRLAKHMASRHKSRNPANDIAKAYSCD 629
               ::.......|...::...|  |.|...|.:..|.|:.|..             :.|:.|:|.
Human   570 ---SFENGHPSQPGPPQLTRAS--ADVLSKCKKALSEHNVLVV-------------EGARKYACK 616

  Fly   630 VCRRSFARSDMLTRHMRLHTGVKPYTCKVCGQVFSRSDHLSTHQRT 675
            :|.::|.......:|:|:|||.|||.|..||:.||:|.||..|.:|
Human   617 ICCKTFLTLTDCKKHIRVHTGEKPYACLKCGKRFSQSSHLYKHSKT 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klu	NP_001261690.1	FYDLN_acid	<182..248	CDD:302856	8/65 (12%)
		C2H2 Zn finger	592..613	CDD:275368	4/20 (20%)
		COG5048	607..>687	CDD:227381	23/69 (33%)
		zf-C2H2	626..648	CDD:278523	6/21 (29%)
		C2H2 Zn finger	628..648	CDD:275368	5/19 (26%)
		zf-H2C2_2	640..665	CDD:290200	12/24 (50%)
		C2H2 Zn finger	656..676	CDD:275368	10/20 (50%)
		zf-H2C2_2	668..690	CDD:290200	4/8 (50%)
		C2H2 Zn finger	684..704	CDD:275368
ZBTB5	NP_055687.1	BTB	14..119	CDD:279045	1/1 (100%)
		BTB	25..119	CDD:197585	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..252		19/133 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..312		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..387		13/63 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..474		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..585		4/39 (10%)
		C2H2 Zn finger	615..635	CDD:275368	5/19 (26%)
		zf-H2C2_2	627..652	CDD:290200	12/24 (50%)
		C2H2 Zn finger	643..662	CDD:275368	9/18 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151358
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930