DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klu and ADR1

DIOPT Version :9

Sequence 1:	NP_001261690.1	Gene:	klu / 39228	FlyBaseID:	FBgn0013469	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_010502.3	Gene:	ADR1 / 851802	SGDID:	S000002624	Length:	1323	Species:	Saccharomyces cerevisiae

Alignment Length:	356	Identity:	73/356 - (20%)
Similarity:	128/356 - (35%)	Gaps:	113/356 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   539 MHHSQVPTTTVGVPVI-------------KGDVASPTTKETV------AWRYNLDVSPVVEEMPP 584
            |.:.:.|....|.||:             |.::...|....:      |.|.|.:...|::..|.
Yeast     1 MANVEKPNDCSGFPVVDLNSCFSNGFNNEKQEIEMETDDSPILLMSSSASRENSNTFSVIQRTPD 65

  Fly   585 GSDVAYVCPTCGQMFS----LHDRLAKHMASRHKSRNPANDIAKAYSCDVCRRSFARSDMLTRHM 645
            |.    :..|...|.|    ..|:|.:::  |...|.|:..: :::.|:||.|:|||.:.|.||.
Yeast    66 GK----IITTNNNMNSKINKQLDKLPENL--RLNGRTPSGKL-RSFVCEVCTRAFARQEHLKRHY 123

  Fly   646 RLHTGVKPYTCKVCGQVFSRSDHLSTH-QRTHTG-----------------------------EK 680
            |.||..|||.|.:|.:.|:|.|.|..| |:.|:|                             :.
Yeast   124 RSHTNEKPYPCGLCNRCFTRRDLLIRHAQKIHSGNLGETISHTKKVSRTITKARKNSASSVKFQT 188

  Fly   681 P-YKCPQ----------------CPYAACRRDMITRHMRTHTR---YDSRGGSREGREGREGREG 725
            | |..|.                .|.|..:|    ::::..||   :.::..|......:...|
Yeast   189 PTYGTPDNGNFLNRTTANTRRKASPEANVKR----KYLKKLTRRASFSAQSASSYALPDQSSLE- 248

  Fly   726 KESRDSRRSNERIE---------EPNSPGSHSLLDMKMNMNMGMGMGLNMGLPMNPMSLLQEELL 781
                  :...:|::         :..:|...|..|:.||:::.:.:..|..:.:|
Yeast   249 ------QHPKDRVKFSTPELVPLDLKNPELDSSFDLNMNLDLNLNLDSNFNIALN---------- 297

  Fly   782 QKSQPGLTLGGPMPLVVKTESAXRCLYAAAS 812
            :....|.|:.....|   .|||....|::.|
Yeast   298 RSDSSGSTMNLDYKL---PESANNYTYSSGS 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klu	NP_001261690.1	FYDLN_acid	<182..248	CDD:302856
		C2H2 Zn finger	592..613	CDD:275368	5/24 (21%)
		COG5048	607..>687	CDD:227381	32/126 (25%)
		zf-C2H2	626..648	CDD:278523	11/21 (52%)
		C2H2 Zn finger	628..648	CDD:275368	11/19 (58%)
		zf-H2C2_2	640..665	CDD:290200	12/24 (50%)
		C2H2 Zn finger	656..676	CDD:275368	8/20 (40%)
		zf-H2C2_2	668..690	CDD:290200	9/68 (13%)
		C2H2 Zn finger	684..704	CDD:275368	4/35 (11%)
ADR1	NP_010502.3	zf-C2H2	104..126	CDD:395048	11/21 (52%)
		C2H2 Zn finger	106..126	CDD:275368	11/19 (58%)
		zf-H2C2_2	118..143	CDD:404364	12/24 (50%)
		C2H2 Zn finger	134..155	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12228
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950