DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klu and Zscan4f

DIOPT Version :9

Sequence 1:	NP_001261690.1	Gene:	klu / 39228	FlyBaseID:	FBgn0013469	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_578644.3	Gene:	Zscan4f / 503124	RGDID:	1563625	Length:	508	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	87/410 - (21%)
Similarity:	136/410 - (33%)	Gaps:	123/410 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 VLPHALLANNSPPPSLPSPPRSESSVTNNVATTTTSSTTKKRSSPKPKGKKGE------------ 417
            :|....||....|.|...|......:.  :||...:|..|..|....:...|:
  Rat   156 ILEQQKLATGLTPESTQMPVHIAEDIL--LATGQENSENKHTSGNSTEVNIGDSSTGHEMNSLLI 218

  Fly   418 -KKPMPPPQERPLDLCMRNEVEPKKYKKSGSKSSLESRSAGMMPPPPALSAASSLESMSALSPAS 481
             :|...|.||..||.....:         |:::                            |..:
  Rat   219 IQKEQCPEQEDGLDSFQFTQ---------GARA----------------------------SQGN 246

  Fly   482 SSHSGHMPITSAATPNHQPPPNSPY---------------ANAMNAAHAAAAAAAAAMIKMEMPL 531
            |||  |:...||.|....|....|.               ..:.||....:|.        .:|:
  Rat   247 SSH--HVEFLSAHTWRDIPMEAQPVIFYRTNISEDREECCTTSKNATQENSAD--------NIPM 301

  Fly   532 HPLH----HQQMHHSQVPTTTVGVPVIKGDVASPTT----KETVAWRYNLDVS---PVVEEMPP- 584
            ..:.    :|:|:|.:.....|...|.:|...||.|    :|::...::.|..   |.|...|.
  Rat   302 RKMDSVFINQRMYHPEPKMGDVSCGVPQGFTRSPGTSTSQQESLGLTFSEDDPRDIPGVPSRPEK 366

  Fly   585 -GSDVA-------------------------YVCPTCGQMFSLHDRLAKHMASRHKSRNPANDIA 623
             .|:..                         |.|..|.:.|.....|:.|..: |:::
  Rat   367 LSSEAVLLYQNQEANSTSKSHQKRLHVGPKQYNCEECPRTFKYASHLSLHQRT-HQNK------- 423

  Fly   624 KAYSCDVCRRSFARSDMLTRHMRLHTGVKPYTCKVCGQVFSRSDHLSTHQRTHTGEKPYKCPQCP 688
            ||:.|..|:::|.|:..|..|..:|...||:.|..|.:.||...:|..|:|.|||||||.|..|.
  Rat   424 KAFVCPTCQKTFKRASDLRCHEIIHNPEKPFKCSTCEKSFSHKTNLKAHERIHTGEKPYVCSLCS 488

  Fly   689 YAACRRDMITRHMRTHTRYD 708
            :..|:.....||:|...:.|
  Rat   489 HRFCQSSTYNRHLRNVHKSD 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klu	NP_001261690.1	FYDLN_acid	<182..248	CDD:302856
		C2H2 Zn finger	592..613	CDD:275368	5/20 (25%)
		COG5048	607..>687	CDD:227381	28/79 (35%)
		zf-C2H2	626..648	CDD:278523	6/21 (29%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..665	CDD:290200	8/24 (33%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		zf-H2C2_2	668..690	CDD:290200	12/21 (57%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
Zscan4f	XP_578644.3	SCAN	53..124	CDD:413396
		SFP1	<349..472	CDD:227516	28/130 (22%)
		zf-C2H2	398..420	CDD:395048	6/22 (27%)
		C2H2 Zn finger	400..420	CDD:275368	5/20 (25%)
		C2H2 Zn finger	428..448	CDD:275368	6/19 (32%)
		zf-C2H2	454..476	CDD:395048	7/21 (33%)
		C2H2 Zn finger	456..476	CDD:275368	7/19 (37%)
		C2H2 Zn finger	484..502	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344838
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930