DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klu and CG2712

DIOPT Version :9

Sequence 1:	NP_001261690.1	Gene:	klu / 39228	FlyBaseID:	FBgn0013469	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	98/557 - (17%)
Similarity:	176/557 - (31%)	Gaps:	187/557 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 EDAEQDEDHDGSVPDEEDDSVDQDGDAGKYIKSEQPVSEDEENEQEMDQDIEDISGEDLELSHSD 253
            :|.|..|....::.|||...|.:..:|..  :.|.|:.::|..:..::|             |.|
  Fly   125 DDQEVTEYPAETIRDEEQLLVVESDEAES--RLEAPIVQEERLDIALEQ-------------HED 174

  Fly   254 D-----NDQDDSPRISMSPLQLQAAQSNLPQDQNQPMNKENPLHVDIKTEIPSPYDRYFPIPSPL 313
            |     :|.|                   |:.:...:.:..|                 .:..|:
  Fly   175 DLCEIVDDPD-------------------PEQRRSRLERSEP-----------------ALQCPI 203

  Fly   314 FGYYLHTKYLNEVFRRRHDLYPSPLQHTPSSIASETETSPNAQERKSSSNHVLPHALLANNSPPP 378
            .|        .::.|:|...|...|...|             :.|:..::|.:...|
  Fly   204 CG--------KQLARKRTFQYHMRLHGQP-------------KIRQEDNDHCIEECL-------- 239

  Fly   379 SLPSPPRSESSVTNNVATTTTSSTTKKRSSPKPKGKKGEKKPMPPPQERPLDLCMRNEVEPKKYK 443
                                       :..|..:.|.||            |:   .|:..|..:
  Fly   240 ---------------------------QVEPVLQAKAGE------------DV---YEIVEKSAQ 262

  Fly   444 KSGSKSSLESRSAGMMPPPPALSAASSLESMSALSPASSSHSGHMPITSAATPNHQPPPNSPYAN 508
            .|.::.:|.|.|....|..|:|......:.:|    .::|...||.:...|||
  Fly   263 TSATQKTLPSGSRPWKPLNPSLQCKICGKQLS----TNNSFKYHMQLHGTATP------------ 311

  Fly   509 AMNAAHAAAAAAAAAMIKMEMPLHPLHHQQMHHSQVPTTTVGVPVIKGDVASPTTKETVAWRYNL 573
                 :.......:...:.....|...|.:.:.::.||            .....::..:.|.:|
  Fly   312 -----YVCTICGESFKTRNARDGHVTLHDRNNPNRCPT------------CFKVYRQASSLRTHL 359

  Fly   574 DVSPVVEEMPPGSDVAYVCPTCGQMFSLHDRLAKHMASRHKSRNPANDIAKAYSCDVCRRSFARS 638
            .:...::        .:.|..||:..:......|||.: |....|       :.||:|.|.|..|
  Fly   360 LIHSGIK--------PFECSICGKRLTQKSGYKKHMLT-HTGEKP-------HGCDICGRRFRYS 408

  Fly   639 DMLTRHMRLHTGVKPYTCKVC-GQVFSRSDHLSTHQRTHTGEKPYKCPQCPYAACRRDMITRHMR 702
            ..|..|.|.|:..||:.|.|| .:.|..:..|:.|...|:.|:|:.|.||..:..||..:..|.:
  Fly   409 SNLIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQ 473

  Fly   703 THTRYDSRGGSREGREGREGREGKESRDSRRSNERIE 739
            :|         :.||:.|.. |.:........:|.:|
  Fly   474 SH---------KAGRQRRRA-EHEVGVQLEEQDENVE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klu	NP_001261690.1	FYDLN_acid	<182..248	CDD:302856	12/58 (21%)
		C2H2 Zn finger	592..613	CDD:275368	6/20 (30%)
		COG5048	607..>687	CDD:227381	27/80 (34%)
		zf-C2H2	626..648	CDD:278523	9/21 (43%)
		C2H2 Zn finger	628..648	CDD:275368	9/19 (47%)
		zf-H2C2_2	640..665	CDD:290200	10/25 (40%)
		C2H2 Zn finger	656..676	CDD:275368	6/20 (30%)
		zf-H2C2_2	668..690	CDD:290200	8/21 (38%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	4/23 (17%)
		C2H2 Zn finger	314..334	CDD:275368	1/19 (5%)
		C2H2 Zn finger	342..362	CDD:275368	4/31 (13%)
		zf-H2C2_2	354..379	CDD:290200	5/32 (16%)
		C2H2 Zn finger	370..390	CDD:275368	6/20 (30%)
		COG5048	378..>463	CDD:227381	29/92 (32%)
		zf-H2C2_2	384..407	CDD:290200	10/30 (33%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	6/20 (30%)
		zf-H2C2_2	439..464	CDD:290200	8/24 (33%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24381
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010