DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klu and ZBTB7C

DIOPT Version :9

Sequence 1:	NP_001261690.1	Gene:	klu / 39228	FlyBaseID:	FBgn0013469	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_016881094.1	Gene:	ZBTB7C / 201501	HGNCID:	31700	Length:	668	Species:	Homo sapiens

Alignment Length:	544	Identity:	121/544 - (22%)
Similarity:	175/544 - (32%)	Gaps:	190/544 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 EPMEMKGDLAEDAEQDEDHDGSVPDEEDDSVDQDGDAGKYIKSEQPVSEDEENEQEMDQDIEDIS 243
            |.||..||..|:.::::|.|    ||:||             .|:...|:||.|::.|.|.||.:
Human   174 EIMEPGGDGGEEDDKEDDDD----DEDDD-------------DEEDEEEEEEEEEDDDDDTEDFA 221

  Fly   244 GEDLELSHSDDNDQDDSPRISMSPLQLQAAQSNLPQDQNQPMNKENPLHVDIKTEIPSPYDRYFP 308
            .:: .|....|.....||  |.:....:.|.|:.|:|........:|.|:.:        .|.|.
Human   222 DQE-NLPDPQDISCHQSP--SKTDHLTEKAYSDTPRDFPDSFQAGSPGHLGV--------IRDFS 275

  Fly   309 IPSPLFGYYLHTKYLNEVFRRRHDLYPSPLQHTPSSIASETETSPNAQERKSS----SNHVLPHA 369
            |.|.|                |.:|||                ..|..:|:.|    :....||.
Human   276 IESLL----------------RENLYP----------------KANIPDRRPSLSPFAPDFFPHL 308

  Fly   370 LLANNSPPPSLPSPPRSESSVTNNVATTTTSSTTKKRSSPKPKGKKGEKKPMPPPQERPLDLCMR 434
            ...:......||..|.....:         ....|.|     |.|:.||:.:|||...|.
Human   309 WPGDFGAFAQLPEQPMDSGPL---------DLVIKNR-----KIKEEEKEELPPPPPPPF----- 354

  Fly   435 NEVEPKKYKKSGSKSSLESRSAGMMPPPPALSAASSLESMSALSPASSSHSGHMPITSAATPNHQ 499
                |..:.|.            |.|..|.          ..|.|..:.:.
Human   355 ----PNDFFKD------------MFPDLPG----------GPLGPIKAEND-------------- 379

  Fly   500 PPPNSPYANAMNAAHAAAAAAAAAMIKMEMPLHPLHHQQMHHSQVPTTTVGVPVIKGDVASPTTK 564
               ...|.|.::|.|.                                        |.:..|
Human   380 ---YGAYLNFLSATHL----------------------------------------GGLFPP--- 398

  Fly   565 ETVAWRYNLDVSPVVEEMPPGSDVAYVCPTCGQMFSLHDRLAKHMASRHKSRNPANDIAKAYSCD 629
                |       |:|||.......:..||.|.::.....:|.:||.: |....|       |.|.
Human   399 ----W-------PLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRT-HTGEKP-------YMCT 444

  Fly   630 VCRRSFARSDMLTRHMRLHTGVKPYTCKVCGQVFSRSDHLSTHQRTHTGEKPYKCPQCPYAACRR 694
            :|...|.|.|.|..|||.|||.:||.|..|...|..:..|..|.|.|||.:||:|..|..:..|.
Human   445 ICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRS 509

  Fly   695 DMITRHMRTHTRYDSRGGSREGRE 718
            |.:.||::..:...:|  .|.||:
Human   510 DHLHRHIKRQSCRMAR--PRRGRK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klu	NP_001261690.1	FYDLN_acid	<182..248	CDD:302856	19/65 (29%)
		C2H2 Zn finger	592..613	CDD:275368	6/20 (30%)
		COG5048	607..>687	CDD:227381	31/79 (39%)
		zf-C2H2	626..648	CDD:278523	10/21 (48%)
		C2H2 Zn finger	628..648	CDD:275368	9/19 (47%)
		zf-H2C2_2	640..665	CDD:290200	12/24 (50%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		zf-H2C2_2	668..690	CDD:290200	10/21 (48%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
ZBTB7C	XP_016881094.1	BTB	73..176	CDD:279045	1/1 (100%)
		BTB	84..177	CDD:197585	1/2 (50%)
		C2H2 Zn finger	415..435	CDD:275368	6/20 (30%)
		zf-H2C2_2	430..452	CDD:290200	8/29 (28%)
		C2H2 Zn finger	443..463	CDD:275368	9/19 (47%)
		zf-H2C2_2	456..480	CDD:290200	12/23 (52%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	483..508	CDD:290200	10/24 (42%)
		C2H2 Zn finger	499..517	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4723
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050